Roles of miRNAs in virus-mediated cellular transformation: lessons from human T-cell leukemia virus type 1

被引：0

作者：

Yeung, Man Lung ^{[2
,3
,4
,5
]}

Jeang, Kuan-Teh ^{[1
]}

机构：

[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Hong Kong, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Res Ctr Infect & Immunol, Hong Kong, Hong Kong, Peoples R China

[4] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[5] Univ Hong Kong, Carol Yu Ctr Infect, Hong Kong, Hong Kong, Peoples R China

来源：

FUTURE VIROLOGY | 2011年 / 6卷 / 11期

关键词：

antagomir; ATL; cancer; HTLV-1; miRNA; RNAi; Tax; MICRORNA EXPRESSION PROFILES; SMALL NONCODING RNAS; HEPATITIS-C VIRUS; TUMOR-SUPPRESSOR; TRANSLATIONAL REPRESSION; TARGET RECOGNITION; REDUCED EXPRESSION; BINDING-PROTEIN; GENE-EXPRESSION; POOR-PROGNOSIS;

D O I：

10.2217/FVL.11.109

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

miRNAs are small noncoding RNAs of similar to 18-25 nucleotides that contribute to the regulation of a diverse variety of biological pathways. Perturbed miRNA expression is seen in many diseases, including cancers. Here, we first discuss the oncogenic and tumor suppressor roles of miRNA, including the roles played by miRNAs in the replication of some oncogenic viruses. Next, using human T-cell leukemia virus type 1 as an example, we discuss the contributions of virus-induced miRNAs in human T-cell leukemia virus type 1-transformation of human cells. Finally, we briefly survey the therapeutic potential of miRNA mimics or anti-miRNAs, antagomirs, to reverse cancer phenotypes.

引用

页码：1351 / 1360

页数：10

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