A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

被引：53

作者：

Cornaggia, Claudio ^{[1
]}

Manoni, Francesco ^{[1
]}

Torrente, Esther ^{[1
]}

Tallon, Sean ^{[1
]}

Connon, Stephen J. ^{[1
]}

机构：

[1] Univ Dublin, Trinity Coll, Ctr Synth & Chem Biol, Trinity Biomed Sci Inst,Sch Chem, Dublin 2, Ireland

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 07期

基金：

欧洲研究理事会;

关键词：

DYNAMIC KINETIC RESOLUTION; CYCLIC ANHYDRIDES; HOMOPHTHALIC ANHYDRIDES; CINCHONA ALKALOIDS; MESO-ANHYDRIDES; METHANOLYTIC DESYMMETRIZATION; BIFUNCTIONAL ORGANOCATALYSTS; STEREOSELECTIVE SYNTHESIS; INDUCED CYCLOADDITION; MICHAEL ADDITION;

D O I：

10.1021/ol300453s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).

引用

页码：1850 / 1853

页数：4

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