Characterization, antifungal and cytotoxic evaluation of green synthesized zinc oxide nanoparticles using Ziziphus nummularia leaf extract

被引：106
作者：
Padalia, Hemali [1 ]
Chanda, Sumitra [1 ]
机构：
[1] Saurashtra Univ, Dept Biosci UGC CAS, Rajkot, Gujarat, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 08期
关键词：
Zinc oxide nanoparticles; green synthesis; Ziziphus nummularia; antifungal activity; cytotoxic activity; SILVER NANOPARTICLES; ZNO NANOPARTICLES; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; CANDIDA-ALBICANS; SIZE; CELL; NANOCRYSTALS; GENOTOXICITY; RESISTANCE;
D O I：
10.1080/21691401.2017.1282868
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Zinc oxide nanoparticles (ZnO NPs) were synthesized using Ziziphus nummularia leaf extract. The characterization was done by various spectral analysis and antifungal (anti-candidal) activity against multidrug resistant clinical isolates and their cytotoxic potential was evaluated. The ZnO NPs were 17.33nm in size and were spherical/irregular in shape. The antifungal activity of ZnO NPs was better than four standard azole antibiotics and they also showed potent cytotoxic effect against HeLa cancer cell line. The results strongly suggest the applicability of green synthesized ZnO NPs as antifungal agent and also its use in cancer diagnosis and treatment.
引用
收藏
页码：1751 / 1761
页数：11
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