Characterization, antifungal and cytotoxic evaluation of green synthesized zinc oxide nanoparticles using Ziziphus nummularia leaf extract

被引：108

作者：

Padalia, Hemali ^{[1
]}

Chanda, Sumitra ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Biosci UGC CAS, Rajkot, Gujarat, India

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 08期

关键词：

Zinc oxide nanoparticles; green synthesis; Ziziphus nummularia; antifungal activity; cytotoxic activity; SILVER NANOPARTICLES; ZNO NANOPARTICLES; PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; CANDIDA-ALBICANS; SIZE; CELL; NANOCRYSTALS; GENOTOXICITY; RESISTANCE;

D O I：

10.1080/21691401.2017.1282868

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Zinc oxide nanoparticles (ZnO NPs) were synthesized using Ziziphus nummularia leaf extract. The characterization was done by various spectral analysis and antifungal (anti-candidal) activity against multidrug resistant clinical isolates and their cytotoxic potential was evaluated. The ZnO NPs were 17.33nm in size and were spherical/irregular in shape. The antifungal activity of ZnO NPs was better than four standard azole antibiotics and they also showed potent cytotoxic effect against HeLa cancer cell line. The results strongly suggest the applicability of green synthesized ZnO NPs as antifungal agent and also its use in cancer diagnosis and treatment.

引用

页码：1751 / 1761

页数：11

共 58 条

[1] Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates [J].

Ali, Khursheed ;

Dwivedi, Sourabh ;

Azam, Ameer ;

Saquib, Quaiser ;

Al-Said, Mansour S. ;

Alkhedhairy, Abdulaziz A. ;

Musarrat, Javed .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 472 :145-156

[2]

Anbukkarasi V, 2015, Int. J. Pharm. Sci. Rev. Res, V33, P110

[3] ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility [J].

Applerot, Guy ;

Lellouche, Jonathan ;

Perkas, Nina ;

Nitzan, Yeshayahu ;

Gedanken, Aharon ;

Banin, Ehud .

RSC ADVANCES, 2012, 2 (06) :2314-2321

[4] Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells [J].

AshaRani, P. V. ;

Mun, Grace Low Kah ;

Hande, Manoor Prakash ;

Valiyaveettil, Suresh .

ACS NANO, 2009, 3 (02) :279-290

[5] Euphorbia heterophylla leaf extract mediated green synthesis of Ag/TiO2 nanocomposite and investigation of its excellent catalytic activity for reduction of variety of dyes in water [J].

Atarod, Monireh ;

Nasrollahzadeh, Mahmoud ;

Sajadi, S. Mohammad .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 462 :272-279

[6]

Awwad A.M., 2014, ADV MAT LETT, V5, P520, DOI DOI 10.5185/AMLETT.2014.5575

[7] Toxicological impact studies based on Escherichia coli bacteria in ultrafine ZnO nanoparticles colloidal medium [J].

Brayner, R ;

Ferrari-Iliou, R ;

Brivois, N ;

Djediat, S ;

Benedetti, MF ;

Fiévet, F .

NANO LETTERS, 2006, 6 (04) :866-870

[8]

Castro L., 2014, Rev. Adv. Sci. Eng., V3, P199

[9]

Chen C, 2000, DIFFR DATA FILE, P36

[10] An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using Eclipta prostrata on Human Liver Carcinoma Cells [J].

Chung, Ill-Min ;

Rahuman, Abdul Abdul ;

Marimuthu, Sampath ;

Kirthi, Arivarasan Vishnu ;

Anbarasan, Karunanithi ;

Rajakumar, Govindasamy .

NANOMATERIALS, 2015, 5 (03) :1317-1330

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