Epstein-Barr virus and breast cancer: Serological study in a high-incidence area of nasopharyngeal carcinoma

被引：45
作者：
He, Jian-Rong [2 ]
Tang, Lu-Ying [4 ]
Yu, Dan-Dan [2 ,5 ]
Su, Feng-Xi [1 ]
Song, Er-Wei [1 ]
Lin, Ying [3 ]
Wang, Shen-Ming [3 ]
Lai, Guan-Chao [6 ]
Chen, Wei-Qing [2 ]
Ren, Ze-Fang [2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China
[5] Shunde Peoples Hosp, Shunde 528300, Peoples R China
[6] Testing Ctr Occupat Hyg, Lab Guangdong, Guangzhou 510300, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2011年 / 309卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Epstein-Barr virus; Immunoglobulin A; Immunoglobulin G; IMMUNOGLOBULIN-G IGG; ASSOCIATION; INFECTION; EBV; RISK; CYTOMEGALOVIRUS; ANTIBODIES; DIAGNOSIS; GENOME; ASSAY;
D O I：
10.1016/j.canlet.2011.05.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05-2.76) (seropositivity) and 2.21 (1.11-4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：128 / 136
页数：9
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