Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum

被引：87
作者：
Shamsa, F
Ahmadiani, A
Khosrokhavar, R
机构：
[1] Shaheed Beheshti Univ Med Sci, Fac Med, Dept Pharmacol, Tehran, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Dept Chem, Tehran, Iran
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 64卷 / 02期
关键词：
barberry; antihistaminic; anticholinergic; guinea-pig ileum;
D O I：
10.1016/S0378-8741(98)00122-6
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Barberry (Berberis vulgaris) is a well known medicinal plant in Iran and has also been used as food. The antihistaminic and anticholinergic activity of aqueous extract of barberry fruits were investigated on isolated guinea-pig ileum, and dose-response curves of histamine and acetylcholine with and without extract were plotted. The pA(2) values for antihistaminic activity of extract and dexchlorpheniramine were calculated (extract; pA(2) +/- S.E.M. = 4.50 +/- 0.01[-log C (g/l)]; dexchlorpheniramine; pA(2) +/- S.E.M. = 9.36 +/- 0.14[-log C (M)]) and compared with each other. The pA(2) values for anticholinergic activity of extract and atropine were also calculated (extract, pA(2) +/- S.E.M. = 4.37 +/- 0.03[-log C (g/l)]; atropine, pA(2) +/- S.E.M. = 8.99 +/- 0.13[-log C (M)]) and compared. The results indicated antihistaminic and anticholinergic activity of extract that seems to be of the competitive type. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：161 / 166
页数：6
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