Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC-MS-MS approach

被引：6

作者：

Adam, Aileen ^{[1
]}

Webster, Lucy M. I. ^{[1
]}

Mullen, William ^{[2
]}

Keller, Lukas F. ^{[1
]}

Johnson, Paul C. D. ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Glasgow, Coll Med Vet & Life Sci, Sch Life Sci Life Sci Anim Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

VETERINARY PARASITOLOGY | 2011年 / 177卷 / 3-4期

关键词：

Anthelmintic; Benzimidazoles; HPLC-MS-MS; Lagopus lagopus scoticus; Parasite control; Trichostrongylus tenuis; DRUG-TREATMENT; BIGHORN SHEEP; ANTHELMINTICS; LUNGWORM;

D O I：

10.1016/j.vetpar.2010.12.013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

On red grouse estates in the UK the nematode parasite Trichostrongylus tenuis is often controlled by application of grit medicated with the anthelmintic fenbendazole (FBZ). To date, assessment of the efficacy has been inhibited by the inability to quantify uptake of FBZ by the birds. We have developed a simple and sensitive HPLC-MS-MS method for detecting and quantifying FBZ and its metabolites from a 300 mg sample of red grouse liver. This method could be used to improve the efficacy of medicated grit treatment by allowing the identification of conditions and application methods that optimize the uptake of FBZ. With the necessary modifications, our method will also be applicable to other wildlife species where self-medication is used for parasite control. (C) 2011 Elsevier B.V. All rights reserved,

引用

页码：383 / 386

页数：4