Influence of TRPV4 gene polymorphisms on the development of osmotic airway hyperresponsiveness in patients with bronchial asthma

被引：10
|
作者：
Naumov, D. E. [1 ]
Kolosov, V. P. [1 ]
Perelman, J. M. [1 ]
Prikhodko, A. G. [1 ]
机构：
[1] Far Eastern Res Ctr Physiol & Pathol Respirat, Ul Kalinina 22, Blagoveshchensk 675000, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 469卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
D O I：
10.1134/S1607672916040074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of single nucleotide polymorphisms (SNP) of TRPV4 gene on the development of airway hyperresponsiveness (39.7% of cases) in response to the decrease in osmolarity under inspiration of distilled water aerosol was studies in 189 patients with uncontrolled bronchial asthma. rs6606743 SNP was found to significantly contribute to the development of osmotic airway hyperresponsiveness. Analysis of the dominant genetic model revealed substantial prevalence of AG + GG genotype frequency in the group of patients with asthma with osmotic hyperresponsiveness in comparison with the patients who had negative response to bronchoprovocation. In addition, carriers of GG or AG genotypes had significantly more profound decrease of lung function parameters in relation to A homozygous patients.
引用
收藏
页码：260 / 263
页数：4
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