Delirium and Sedation in the ICU

被引:46
作者
Frontera, Jennifer A. [1 ,2 ]
机构
[1] Mt Sinai Sch Med, Neurosci Intens Care Unit, Dept Neurosurg, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
关键词
Delirium; Sedation; ICU; Intensive care; Confusion; Neurocritical care; INTENSIVE-CARE-UNIT; MECHANICALLY VENTILATED PATIENTS; CRITICALLY-ILL PATIENTS; NICOTINE REPLACEMENT THERAPY; DOSE INTRAVENOUS HALOPERIDOL; POSTOPERATIVE DELIRIUM; STATUS EPILEPTICUS; AGITATED DELIRIUM; RISK-FACTORS; STROKE;
D O I
10.1007/s12028-011-9520-0
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Delirium is defined by a fluctuating level of attentiveness and has been associated with increased ICU mortality and poor cognitive outcomes in both general ICU and neurocritical care populations. Sedation use in the ICU can contribute to delirium. Limiting ICU sedation allows for the diagnosis of underlying acute neurological insults associated with delirium and leads to shorter mechanical ventilation time, shorter length of stay, and improved 1 year mortality rates. Identifying the underlying etiology of delirium is critical to developing treatment paradigms.
引用
收藏
页码:463 / 474
页数:12
相关论文
共 75 条
[11]   Preoperative risk assessment for delirium after noncardiac surgery: A systematic review [J].
Dasgupta, Mondipa ;
Dumbrell, Andrea C. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2006, 54 (10) :1578-1589
[12]   Efficacy and safety of quetiapine in critically ill patients with delirium: A prospective, multicenter, randomized, double-blind, placebo-controlled pilot study [J].
Devlin, John W. ;
Roberts, Russel J. ;
Fong, Jeffrey J. ;
Skrobik, Yoanna ;
Riker, Richard R. ;
Hill, Nicholas S. ;
Robbins, Tracey ;
Garpestad, Erik .
CRITICAL CARE MEDICINE, 2010, 38 (02) :419-427
[13]   POSTOPERATIVE DELIRIUM - A REVIEW OF 80 PRIMARY DATA-COLLECTION STUDIES [J].
DYER, CB ;
ASHTON, CM ;
TEASDALE, TA .
ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (05) :461-465
[14]   INTRASUBJECT REPRODUCIBILITY OF GROWTH HORMONE-RELEASING HORMONE-STIMULATED GROWTH-HORMONE IN OLDER WOMEN, OLDER MEN, AND YOUNGER MEN [J].
DYSKEN, MW ;
SKARE, SS ;
BURKE, MS ;
MACH, JR ;
GALKA, T ;
BILLINGTON, CJ .
BIOLOGICAL PSYCHIATRY, 1993, 33 (8-9) :610-617
[15]   Delirium in mechanically ventilated patients - Validity and reliability of the Confusion Assessment Method for the intensive care unit (CAM-ICU) [J].
Ely, EW ;
Inouye, SK ;
Bernard, GR ;
Gordon, S ;
Francis, J ;
May, L ;
Truman, B ;
Speroff, T ;
Gautam, S ;
Margolin, R ;
Hart, RP ;
Dittus, R .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (21) :2703-2710
[16]   Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit [J].
Ely, EW ;
Shintani, A ;
Truman, B ;
Speroff, T ;
Gordon, SM ;
Harrell, FE ;
Inouye, SK ;
Bernard, GR ;
Dittus, RS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (14) :1753-1762
[17]   Delirium superimposed on dementia: A systematic review [J].
Fick, DM ;
Agostini, JV ;
Inouye, SK .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (10) :1723-1732
[18]   Sleep and delirium in ICU patients: a review of mechanisms and manifestations [J].
Figueroa-Ramos, Milagros I. ;
Arroyo-Novoa, Carmen Mabel ;
Lee, Kathryn A. ;
Padilla, Geraldine ;
Puntillo, Kathleen A. .
INTENSIVE CARE MEDICINE, 2009, 35 (05) :781-795
[19]   Neural mechanisms of delirium: Current hypotheses and evolving concepts [J].
Flacker, JM ;
Lipsitz, LA .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (06) :B239-B246
[20]   DELIRIUM IN OLDER PATIENTS [J].
FRANCIS, J .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1992, 40 (08) :829-838