Progress in understanding the molecular mechanism of Xist RNA function through genetics

被引：12

作者：

Monfort, Asun ^{[1
]}

Wutz, Anton ^{[1
]}

机构：

[1] ETH Honggerberg, Swiss Fed Inst Technol, Dept Biol, Inst Mol Hlth Sci, Otto Stern Weg 7, CH-8049 Zurich, Switzerland

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2017年 / 372卷 / 1733期

基金：

瑞士国家科学基金会;

关键词：

noncoding RNA; gene regulation; chromatin; histone modification; X chromosome inactivation; Xist; INACTIVE X-CHROMOSOME; EMBRYONIC STEM-CELLS; HISTONE H3; HNRNP U; DOSAGE COMPENSATION; MALE DROSOPHILA; SAF-A; MOUSE; METHYLATION; GENES;

D O I：

10.1098/rstb.2016.0368

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Xist gene produces a long noncoding RNA that initiates chromosomewide gene repression on the inactive X chromosome in female mammals. Recent progress has advanced the understanding of Xist function at the molecular level. This review provides an overview of insights from genetic approaches and puts the new data in the context of an emerging mechanistic model as well as the existing literature. Some consideration is given on how independent biochemical studies on X inactivation help to advance on the wider question of chromatin regulation in the mammalian dosage compensation system. This article is part of the themed issue 'X-chromosome inactivation: a tribute to Mary Lyon'.

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页数：9

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