Background: Larrea tridentata is a dominant shrub in the deserts of North America and is recognized for its various traditional uses. More than 50 traditional uses have been recorded. Re-garding its chemical composition, the products of the mevalonate, shikimate, and malonate path-ways are predominant. L. tridentata has nordihydroguaiaretic acid (NDGA), one of its most studied secondary metabolites that exhibited remarkable different biological activities: sequestration of re-active oxygen species, inhibition of lipoxygenases (LOX) and activation of the endogenous antioxi-dant response mediated by nuclear factor erythroid 2-related factor 2 (NRF2). Objective and Methods: This review seeks to draw attention to metabolites other than NDGA and which also contribute to the various biological activities of L. tridentata. Therefore, the present re-view includes those reports focused on the pharmacological properties of the organic extracts of L. tridentata and its natural products with promising values. Results and Conclusion: Among the most promising and widely reported metabolites from L. tri-dentata, are: 3'-demethoxy-6-O-demethylisoguaiacin, 3'-O-methyldihydroguaiaretic acid, meso-di-hydroguaiaretic acid, and tetra-O-methylnordihydroguaiaretic acid. These have been reported to ex-hibit antibacterial, antiprotozoal, anthelmintic, antifungal, antiviral, anticancer, and antioxidant ac-tivities.