Sinus Node Dysfunction Co-occurring with Immune Checkpoint Inhibitor-associated Myocarditis

被引：8

作者：

Nishikawa, Tatsuya ^{[1
]}

Kunimasa, Kei ^{[2
]}

Ohta-Ogo, Keiko ^{[3
]}

Ikeda, Yoshihiko ^{[3
]}

Yasui, Taku ^{[1
]}

Shioyama, Wataru ^{[1
]}

Oka, Toru ^{[1
]}

Honma, Keiichiro ^{[4
]}

Hatakeyama, Kinta ^{[3
]}

Kumagai, Toru ^{[2
]}

Fujita, Masashi ^{[1
]}

机构：

[1] Osaka Int Canc Inst, Dept Oncocardiol, Osaka, Japan

[2] Osaka Int Canc Inst, Dept Thorac Oncol, Osaka, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Suita, Osaka, Japan

[4] Osaka Int Canc Inst, Dept Pathol, Osaka, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 14期

关键词：

case report; cardio-oncology; sick sinus syndrome; pembrolizumab; immune-related adverse event; myocarditis; EVENTS;

D O I：

10.2169/internalmedicine.8575-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint inhibitor (ICI)-induced myocarditis is a potentially life-threatening adverse event. We herein report a rare case of sick sinus syndrome (SSS) co-occurring with ICI-associated myocarditis. A 71 -year-old woman with lung cancer undergoing pembrolizumab monotherapy was admitted owing to a fever, worsening kidney function, and sinus bradycardia. She was diagnosed with multi-organ immune-related ad-verse events, including myocarditis. Pulse steroid therapy was initiated immediately under the support of a temporary pacemaker, which resulted in the resolution of SSS in a few days. Biopsy specimens of the endo-myocardium showed active myocarditis. Thus, we should be aware that SSS can co-occur with ICI-induced myocarditis.

引用

页码：2161 / 2165

页数：5

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