Ageing How overnight fasting could extend lifespan

被引：3

作者：

Helfand, Stephen L. ^{[1
]}

de Cabo, Rafael ^{[2
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Div Biol & Med, Providence, RI 02912 USA

[2] NIA, Intramural Res Program, Translat Gerontol Branch, Baltimore, MD 21224 USA

来源：

NATURE | 2021年 / 598卷 / 7880期

关键词：

Ageing; Metabolism; Physiology; Nutrition; HEALTH;

D O I：

10.1038/d41586-021-01578-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A feeding schedule of prolonged overnight fasting periods extends healthy lifespan in fruit flies by promoting night-time autophagy, a process in which material in cells is degraded and recycled.

引用

页码：265 / 266

页数：2

共 12 条

[1] Effects of Intermittent Fasting on Health, Aging, and Disease [J].

de Cabo, Rafael ;

Mattson, Mark P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (26) :2541-2551

[2] The metabolic regulation of aging [J].

Finkel, Toren .

NATURE MEDICINE, 2015, 21 (12) :1416-1423

[3]

Hansen M, 2018, NAT REV MOL CELL BIO, V19, P579, DOI 10.1038/s41580-018-0033-y

[4] Proteostasis and aging [J].

Kaushik, Susmita ;

Cuervo, Ana Maria .

NATURE MEDICINE, 2015, 21 (12) :1406-1415

[5] Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan [J].

Longo, Valter D. ;

Panda, Satchidananda .

CELL METABOLISM, 2016, 23 (06) :1048-1059

[6] Caloric restriction improves health and survival of rhesus monkeys [J].

Mattison, Julie A. ;

Colman, Ricki J. ;

Beasley, T. Mark ;

Allison, David B. ;

Kemnitz, Joseph W. ;

Roth, George S. ;

Ingram, Donald K. ;

Weindruch, Richard ;

de Cabo, Rafael ;

Anderson, Rozalyn M. .

NATURE COMMUNICATIONS, 2017, 8

[7] Meal frequency and timing in health and disease [J].

Mattson, Mark P. ;

Allison, David B. ;

Fontana, Luigi ;

Harvie, Michelle ;

Longo, Valter D. ;

Malaisse, Willy J. ;

Mosley, Michael ;

Notterpek, Lucia ;

Ravussin, Eric ;

Scheer, Frank A. J. L. ;

Seyfried, Thomas N. ;

Varady, Krista A. ;

Panda, Satchidananda .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (47) :16647-16653

[8] Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories [J].

Mitchell, Sarah J. ;

Bernier, Michel ;

Mattison, Julie A. ;

Aon, Miguel A. ;

Kaiser, Tamzin A. ;

Anson, R. Michael ;

Ikeno, Yuji ;

Anderson, Rozalyn M. ;

Ingram, Donald K. ;

de Cabo, Rafael .

CELL METABOLISM, 2019, 29 (01) :221-+

[9] Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans [J].

Stekovic, Slaven ;

Hofer, Sebastian J. ;

Tripolt, Norbert ;

Aon, Miguel A. ;

Royer, Philipp ;

Pein, Lukas ;

Stadler, Julia T. ;

Pendl, Tobias ;

Prietl, Barbara ;

Url, Jasmin ;

Schroeder, Sabrina ;

Tadic, Jelena ;

Eisenberg, Tobias ;

Magnes, Christoph ;

Stumpe, Michael ;

Zuegner, Elmar ;

Bordag, Natalie ;

Riedl, Regina ;

Schmidt, Albrecht ;

Kolesnik, Ewald ;

Verheyen, Nicolas ;

Springer, Anna ;

Madl, Tobias ;

Sinner, Frank ;

de Cabo, Rafael ;

Kroemer, Guido ;

Obermayer-Pietsch, Barbara ;

Dengjel, Joem ;

Sourij, Harald ;

Pieber, Thomas R. ;

Madeo, Frank .

CELL METABOLISM, 2019, 30 (03) :462-+

[10] Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes [J].

Sutton, Elizabeth F. ;

Beyl, Robbie ;

Early, Kate S. ;

Cefalu, William T. ;

Ravussin, Eric ;

Peterson, Courtney M. .

CELL METABOLISM, 2018, 27 (06) :1212-+

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