Codrug: An efficient approach for drug optimization

被引：84
作者：
Das, N. [1 ]
Dhanawat, M. [1 ]
Dash, B. [1 ]
Nagarwal, R. C. [1 ]
Shrivastava, S. K. [1 ]
机构：
[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 41卷 / 05期
关键词：
Codrug; Mutual prodrug; Drug delivery; MUTUAL PRODRUG; L-DOPA; IN-VITRO; PROLIFERATIVE VITREORETINOPATHY; 5-AMINOSALICYLIC ACID; CO-DRUG; PHARMACOLOGICAL EVALUATION; TRIAMCINOLONE ACETONIDE; URSODEOXYCHOLIC ACID; PARKINSONS-DISEASE;
D O I：
10.1016/j.ejps.2010.09.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Codrug or mutual prodrug is an approach where various effective drugs, which are associated with some drawbacks, can be modified by attaching with other drugs of same or different categories directly or via a linkage. More appropriately one can say combining two different pharmacophores with similar or different pharmacological activities elicit synergistic action or help to target the parent drug to specific site/organ/cells respectively. This approach is commonly used to improve physicochemical, biopharmaceutical and drug delivery properties of therapeutic agents. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：571 / 588
页数：18
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