Application of bis-2-(trimethylsilyl)ethyl diselenide to the synthesis of selenium-containing amino acid derivatives

被引：2

作者：

Yonezawa, Tsubasa ^{[1
]}

Yamaguchi, Masahito ^{[1
]}

Ninomiya, Masayuki ^{[1
,2
]}

Koketsu, Mamoru ^{[1
,2
]}

机构：

[1] Gifu Univ, Dept Mat Sci & Technol, Fac Engn, 1-1 Yanagido, Gifu 5011193, Japan

[2] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, 1-1 Yanagido, Gifu 5011193, Japan

来源：

TETRAHEDRON | 2017年 / 73卷 / 42期

关键词：

Selenation; Bis-2-(trimethylsilyl)ethyl diselenide; Selenium-containing amino acid; Selenocysteine; Selenoglutathione; DEPENDENT GLUTATHIONE-PEROXIDASE; MOLECULAR-BIOLOGY; PHYSIOLOGICAL ROLES; SELENOCYSTEINE; SELENOPROTEINS; METABOLISM; PROTEIN;

D O I：

10.1016/j.tet.2017.09.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In this study, a series of selenocysteine (Sec) and selenoglutathione (GSeH) derivatives were synthesized via 2-(trimethylsilyl)ethylselenation as a key step. Our findings suggested the relevance and application of a 2-(trimethylsilyl)ethylselenyl group to the Se-containing amino acid synthesis. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：6085 / 6091

页数：7

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