Severe asthma and quality of life

被引：82

作者：

Hossny, Elham ^{[1
]}

Caraballo, Luis ^{[2
]}

Casale, Thomas ^{[3
]}

El-Gamal, Yehia ^{[1
]}

Rosenwasser, Lanny ^{[4
]}

机构：

[1] Ain Shams Univ, Pediat Allergy & Immunol Unit, Childrens Hosp, 40A Baghdad St, Cairo 11341, Egypt

[2] Univ Cartagena, Inst Immunol Res, Cartagena, Colombia

[3] Univ S Florida, Morsani Coll Med, Div Allergy & Immunol, Dept Internal Med, Tampa, FL USA

[4] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2017年 / 10卷

关键词：

Severe asthma; Quality of life; Biologics; Adherence; Monoclonal antibodies; SEVERE ALLERGIC-ASTHMA; ADD-ON THERAPY; DOUBLE-BLIND; PERSISTENT ASTHMA; INHALED CORTICOSTEROIDS; UNCONTROLLED ASTHMA; MONOCLONAL-ANTIBODY; HEALTH-SERVICE; SLEEP QUALITY; OMALIZUMAB;

D O I：

10.1186/s40413-017-0159-y

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Severe asthma has a great impact on the quality of life (QOL) of patients and their families. The magnitude of this morbidity is affected by several personal factors including age. Appropriate asthma control and modifications of social roles and activities are expected to improve QOL. Biologics, primarily monoclonal antibodies, have been developed to target specific pathways and molecules important in the pathogenesis of asthma. The use of biologics has shown some promising effects on the QOL of patients with severe recalcitrant asthma. Other potential measures involve targeting risk factors and comorbidities and improving the levels of adherence to therapy. This article briefly reviews the impact of severe asthma on QOL and the potential methods to combat this morbidity including the available therapeutic biologics.

引用

页数：8

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