Modulation of purinergic neurotransmission by ecto-ATPase

被引：19

作者：

Kennedy, C

Westfall, TD

Sneddon, P

机构：

[1] Dept. of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow G1 1XW

来源：

SEMINARS IN NEUROSCIENCE | 1996年 / 8卷 / 04期

基金：

英国惠康基金;

关键词：

ARL; 67156; ATP; ecto-ATPase; purinergic; vas deferens;

D O I：

10.1006/smns.1996.0025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of ecto-ATPase in modulating the purinergic component of neurotransmission in the guinea-pig vas deferens has been investigated using ARL 67156, a recently developed inhibitor of ecto-ATPase. ARL 67156 rapidly and reversibly potentiated neurogenic contractions in a concentration-dependent manner ARL 67156 also potentiated contractions evoked by exogenous ATP, but had no effect on those to the stable analogue alpha,beta-methyleneATP or on those to noradrenaline and KCl in the presence of the P-2-purinoceptor antagonist PPADS. These results are consistent with an inhibitory action of ARL 67156 on ecto-ATPase and suggest that ecto-ATPase modulates purinergic neurotransmission in the guinea-pig vas deferens. (C) 1996 Academic Press Ltd

引用

页码：195 / 199

页数：5

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