Landscape Mapping of Functional Proteins in Insulin Signal Transduction and Insulin Resistance: A Network-Based Protein-Protein Interaction Analysis

被引：19

作者：

Chakraborty, Chiranjib ^{[2
]}

Roy, Sanjiban S. ^{[3
]}

Hsu, Minna J. ^{[1
]}

Agoramoorthy, Govindasamy ^{[4
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan

[2] VIT Univ, Sch Biosci & Technol, Vellore, Tamil Nadu, India

[3] VIT Univ, Sch Comp Sci & Engn, Vellore, Tamil Nadu, India

[4] Tajen Univ, Coll Environm & Hlth Sci, Yanpu, Taiwan

来源：

PLOS ONE | 2011年 / 6卷 / 01期

关键词：

DATABASE; 3-KINASE; MATRIX;

D O I：

10.1371/journal.pone.0016388

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The type 2 diabetes has increased rapidly in recent years throughout the world. The insulin signal transduction mechanism gets disrupted sometimes and it's known as insulin-resistance. It is one of the primary causes associated with type-2 diabetes. The signaling mechanisms involved several proteins that include 7 major functional proteins such as INS, INSR, IRS1, IRS2, PIK3CA, Akt2, and GLUT4. Using these 7 principal proteins, multiple sequences alignment has been created. The scores between sequences also have been developed. We have constructed a phylogenetic tree and modified it with node and distance. Besides, we have generated sequence logos and ultimately developed the protein-protein interaction network. The small insulin signal transduction protein arrangement shows complex network between the functional proteins.

引用

页数：7

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