Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study

被引：102

作者：

Yoshita, Mitsuhiro ^{[1
,2
]}

Arai, Heii ^{[3
]}

Arai, Hiroyuki ^{[4
]}

Arai, Tetsuaki ^{[5
]}

Asada, Takashi ^{[5
]}

Fujishiro, Hiroshige ^{[6
]}

Hanyu, Haruo ^{[7
]}

Iizuka, Osamu ^{[8
]}

Iseki, Eizo ^{[6
]}

Kashihara, Kenichi ^{[9
]}

Kosaka, Kenji ^{[10
]}

Maruno, Hirotaka ^{[11
]}

Mizukami, Katsuyoshi ^{[12
]}

Mizuno, Yoshikuni ^{[13
]}

Mori, Etsuro ^{[8
]}

Nakajima, Kenichi ^{[14
]}

Nakamura, Hiroyuki ^{[15
]}

Nakano, Seigo ^{[16
]}

Nakashima, Kenji ^{[17
]}

Nishio, Yoshiyuki ^{[8
]}

Orimo, Satoshi ^{[18
]}

Samuraki, Miharu ^{[1
]}

Takahashi, Akira ^{[19
]}

Taki, Junichi ^{[14
]}

Tokuda, Takahiko ^{[20
]}

Urakami, Katsuya ^{[21
]}

Utsumi, Kumiko ^{[22
]}

Wada, Kenji ^{[17
]}

Washimi, Yukihiko ^{[23
]}

Yamasaki, Junichi ^{[24
]}

Yamashina, Shouhei ^{[24
]}

Yamada, Masahito ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Neurol & Neurobiol Aging, Grad Sch Med Sci, Kanazawa, Ishikawa 9208640, Japan

[2] Hokuriku Natl Hosp, Dept Neurol, Nanto, Toyama 9391893, Japan

[3] Juntendo Univ, Sch Med, Dept Psychiat, Bunkyo Ku, Tokyo 1138431, Japan

[4] Tohoku Univ, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan

[5] Univ Tsukuba, Inst Clin Med, Dept Neuropsychiat, Tsukuba, Ibaraki 3058576, Japan

[6] Juntendo Univ, Sch Med, PET CT Dementia Res Ctr, Juntendo Tokyo Koto Geriatr Med Ctr,Koto Ku, Tokyo 1360075, Japan

[7] Tokyo Med Univ, Dept Geriatr Med, Shinjuku Ku, Tokyo 1600023, Japan

[8] Tohoku Univ, Dept Behav Neurol & Cognit Neurosci, Grad Sch Med, Sendai, Miyagi 9808575, Japan

[9] Okayama Kyokuto Hosp, Dept Neurol, Okayama 7038265, Japan

[10] Med Care Court Clin, Yokohama, Kanagawa 2250014, Japan

[11] Toranomon Gen Hosp, Dept Radiol, Minato Ku, Tokyo 1058470, Japan

[12] Univ Tsukuba, Grad Sch Comprehens Human Sci, Bunkyo Ku, Tokyo 1120012, Japan

[13] Kitasato Univ, Div Neurogenerat Med, Dept Neurol, Sch Med, Sagamihara, Kanagawa 2520374, Japan

[14] Kanazawa Univ Hosp, Dept Nucl Med, Kanazawa, Ishikawa 9208640, Japan

[15] Kanazawa Univ, Grad Sch Med Sci, Dept Environm & Prevent Med, Kanazawa, Ishikawa 9208640, Japan

[16] Med Co LTA, Ctr Treatment Care & Res Dementia, Sumida Ku, Tokyo 1300004, Japan

[17] Tottori Univ, Fac Med, Div Neurol, Dept Brain & Neurosci, Yonago, Tottori 6838504, Japan

[18] Mutual Aid Assoc Publ Sch Teachers, Dept Neurol, Kanto Cent Hosp, Tokyo 1588531, Japan

[19] Tokai Cent Hosp, Kakamigahara, Gifu 5040816, Japan

[20] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Pathobiol Brain Dis, Kyoto 6020841, Japan

[21] Tottori Univ, Sch Hlth Sci, Fac Med, Dept Regulat Biol, Yonago, Tottori 6838503, Japan

[22] Sunagawa City Med Ctr, Dept Neuropsychiat, Sunagawa, Hokkaido 0730196, Japan

[23] Hosp Natl Ctr Geriatr & Gerontol, Dept Cognit Disorders, Obu, Aichi 4748511, Japan

[24] Toho Univ, Ohmori Hosp, Div Cardiovasc Med, Dept Internal Med,Sch Med, Ota, Tokyo 1438541, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 03期

关键词：

ALZHEIMERS-DISEASE; DIFFERENTIAL-DIAGNOSIS; PARKINSONS-DISEASE; CLINICAL-DIAGNOSIS; SENILE DEMENTIA; BODY TYPE; FP-CIT; DLB; CARDIOMYOPATHY; CONSORTIUM;

D O I：

10.1371/journal.pone.0120540

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background and Purpose Dementia with Lewy bodies (DLB) needs to be distinguished from Alzheimer's disease (AD) because of important differences in patient management and outcome. Severe cardiac sympathetic degeneration occurs in DLB, but not in AD, offering a potential system for a biological diagnostic marker. The primary aim of this study was to investigate the diagnostic accuracy, in the ante-mortem differentiation of probable DLB from probable AD, of cardiac imaging with the ligand I-123-meta-iodobenzylguanidine (MIBG) which binds to the noradrenaline reuptake site, in the first multicenter study. Methods We performed a multicenter study in which we used I-123-MIBG scans to assess 133 patients with clinical diagnoses of probable (n = 61) or possible (n = 26) DLB or probable AD (n = 46) established by a consensus panel. Three readers, unaware of the clinical diagnosis, classified the images as either normal or abnormal by visual inspection. The heart-to-mediastinum ratios of I-123-MIBG uptake were also calculated using an automated region-of-interest based system. Results Using the heart-to-mediastinum ratio calculated with the automated system, the sensitivity was 68.9% and the specificity was 89.1% to differentiate probable DLB from probable AD in both early and delayed images. By visual assessment, the sensitivity and specificity were 68.9% and 87.0%, respectively. In a subpopulation of patients with mild dementia (MMSE >= 22, n = 47), the sensitivity and specificity were 77.4% and 93.8%, respectively, with the delayed heart-to-mediastinum ratio. Conclusions Our first multicenter study confirmed the high correlation between abnormal cardiac sympathetic activity evaluated with I-123-MIBG myocardial scintigraphy and a clinical diagnosis of probable DLB. The diagnostic accuracy is sufficiently high for this technique to be clinically useful in distinguishing DLB from AD, especially in patients with mild dementia.

引用

页数：13

共 50 条

[21] Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies
Tang, Zhihui
Hirano, Shigeki
Koizumi, Yume
Izumi, Michiko
Kitayama, Yoshihisa
Yamagishi, Kosuke
Tamura, Mitsuyoshi
Ishikawa, Ai
Kashiwado, Kouichi
Iimori, Takashi
Mukai, Hiroki
Yokota, Hajime
Horikoshi, Takuro
Uno, Takashi
Kuwabara, Satoshi
JOURNAL OF ALZHEIMERS DISEASE, 2024, 100 (01) : 127 - 137
[22] A comparison of visual and semiquantitative analysis methods for planar cardiac 123I-MIBG scintigraphy in dementia with Lewy bodies
Roberts, Gemma
Kane, Joseph P. M.
Lloyd, Jim J.
Petrides, George S.
Howe, Kim
O'Brien, John T.
Thomas, Alan J.
NUCLEAR MEDICINE COMMUNICATIONS, 2019, 40 (07) : 734 - 743
[23] Diagnostic Performance of Myocardial Innervation Imaging Using MIBG Scintigraphy in Differential Diagnosis between Dementia with Lewy Bodies and Other Dementias: A Systematic Review and a Meta-Analysis
Treglia, Giorgio
Cason, Ernesto
Giordano, Alessandro
JOURNAL OF NEUROIMAGING, 2012, 22 (02) : 111 - 117
[24] Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy study
Wada-Isoe, Kenji
Kitayama, Michio
Nakaso, Kazuhiro
Nakashima, Kenji
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 260 (1-2) : 33 - 37
[25] Accuracy of clinical diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis
Rizzo, Giovanni
Arcuti, Simona
Copetti, Massimiliano
Alessandria, Maria
Savica, Rodolfo
Fontana, Andrea
Liguori, Rocco
Logroscino, Giancarlo
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 (04) : 358 - 366
[26] Comparison of 123I-MIBG myocardial scintigraphy, brain perfusion SPECT, and voxel-based MRI morphometry for distinguishing between dementia with Lewy bodies and Alzheimer's disease
Inui, Yoshitaka
Toyama, Hiroshi
Manabe, Yuta
Sarai, Masayoshi
Iwata, Nakao
ANNALS OF NUCLEAR MEDICINE, 2014, 28 (08) : 796 - 804
[27] Early detection of dementia with Lewy bodies in patients with amnestic mild cognitive impairment using 123I-MIBG cardiac scintigraphy
Fujishiro, Hiroshige
Nakamura, Shinichiro
Kitazawa, Maiko
Sato, Kiyoshi
Iseki, Eizo
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 315 (1-2) : 115 - 119
[28] A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
Nalls, Michael A.
Duran, Raquel
Lopez, Grisel
Kurzawa-Akanbi, Marzena
McKeith, Ian G.
Chinnery, Patrick F.
Morris, Christopher M.
Theuns, Jessie
Crosiers, David
Cras, Patrick
Engelborghs, Sebastiaan
De Deyn, Peter Paul
Van Broeckhoven, Christine
Mann, David M. A.
Snowden, Julie
Pickering-Brown, Stuart
Halliwell, Nicola
Davidson, Yvonne
Gibbons, Linda
Harris, Jenny
Sheerin, Una-Marie
Bras, Jose
Hardy, John
Clark, Lorraine
Marder, Karen
Honig, Lawrence S.
Berg, Daniela
Maetzler, Walter
Brockmann, Kathrin
Gasser, Thomas
Novellino, Fabiana
Quattrone, Aldo
Annesi, Grazia
De Marco, Elvira Valeria
Rogaeva, Ekaterina
Masellis, Mario
Black, Sandra E.
Bilbao, Juan M.
Foroud, Tatiana
Ghetti, Bernardino
Nichols, William C.
Pankratz, Nathan
Halliday, Glenda
Lesage, Suzanne
Klebe, Stephan
Durr, Alexandra
Duyckaerts, Charles
Brice, Alexis
Giasson, Benoit I.
Trojanowski, John Q.
JAMA NEUROLOGY, 2013, 70 (06) : 727 - 735
[29] [123I]Meta-iodobenzylguanidine myocardial scintigraphy differentiates corticobasal degeneration from Parkinson's disease
Orimo, S
Ozawa, E
Nakade, S
Hattori, H
Tsuchiya, K
Taki, K
Takahashi, A
INTERNAL MEDICINE, 2003, 42 (01) : 127 - 128
[30] Comparative value of brain perfusion SPECT and [123I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer’s disease
Haruo Hanyu
Soichiro Shimizu
Kentaro Hirao
Hidekazu Kanetaka
Toshihiko Iwamoto
Taishiro Chikamori
Yasuhiro Usui
Akira Yamashina
Kiyoshi Koizumi
Kimihiko Abe
European Journal of Nuclear Medicine and Molecular Imaging, 2006, 33 : 248 - 253

← 1 2 3 4 5 →