Myasthenia gravis in Ceara, Brazil Clinical and epidemiological aspects

被引:14
|
作者
Xavier Aguiar, Aline de Almeida [1 ]
Carvalho, Andre Ferrer [2 ]
de Castro Costa, Carlos Mauricio [3 ]
Aragao Fernandes, Jose Marcelino [4 ]
Costa D'Almeida, Jose Artur [5 ]
Teixeira de Arruda Furtado, Luis Edmundo [6 ]
Bezerra da Cunha, Francisco Marcos [7 ]
机构
[1] Sao Marcos Hosp, Teresina, PI, Brazil
[2] Univ Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, CE, Brazil
[3] Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, CE, Brazil
[4] Univ Fed Ceara, Univ Hosp Walter Cantidio, Neurol Serv, Fortaleza, CE, Brazil
[5] Fortaleza Gen Hosp, Neurol Serv, Fortaleza, CE, Brazil
[6] Univ Fed Ceara, Fac Med, Sobral, CE, Brazil
[7] Univ Fed Ceara, Fac Med, Barbalha, CE, Brazil
关键词
myasthenia gravis; clinical evaluation; epidemiology; LONG-TERM-FOLLOW; ACETYLCHOLINE-RECEPTOR; PREVALENCE;
D O I
10.1590/S0004-282X2010000600003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A retrospective chart review was performed on patients diagnosed as having myasthenia gravis in Ceara State, Brazil and who were followed from October 1981 to June 2009. Clinical and epidemiologic aspects were evaluated. In this work, 122 patients were studied, of whom 85 (69.7%) were females and 37 (30.3%) were males. The disease duration ranged from five months to 50 years (8.9 +/- 8.1 years). Age at the first symptoms varied from 0 to 74 years (31.9 +/- 14.4 years). The first main symptoms and signs were ptosis, diplopia and limb weakness. Generalized myasthenia was the most common clinical presentation, but 5.1% (n=6) persisted as ocular myasthenia. Thymectomy was performed in 42.6% (n=52) of myasthenic patients. A thymoma was present in 10 patients. Serum acetylcholine receptor (AChR) antibodies were present in 80% (n=20) of specimens tested. The data presented are similar to those of studies performed in other countries.
引用
收藏
页码:843 / 848
页数:6
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