Acute ataxia, Graves' disease, and stiff person syndrome

被引：9
作者：
Chia, Su-Ynn
Chua, Richard
Lo, Yew-Long
Wong, Meng-Cheong
Chan, Ling-Ling
Tan, Eng-King
机构：
[1] Singapore Gen Hosp, Natl Inst Neurosci, Dept Neurol, Singapore 0316, Singapore
[2] Singapore Gen Hosp, Dept Endocrinol, Singapore 0316, Singapore
[3] Singapore Gen Hosp, Dept Radiol, Singapore 0316, Singapore
来源：
MOVEMENT DISORDERS | 2007年 / 22卷 / 13期
关键词：
graves' disease; stiff person syndrome; ataxia;
D O I：
10.1002/mds.21703
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years. (C) 2007 Movement Disorder Society.
引用
收藏
页码：1969 / 1971
页数：3
相关论文
共 12 条
[1]   High-dose intravenous immune globulin for stiff-person syndrome [J].
Dalakas, MC ;
Fujii, M ;
Li, M ;
Lutfi, B ;
Kyhos, J ;
McElroy, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (26) :1870-1876
[2]   Stiff person syndrome -: Quantification, specificity, and intrathecal synthesis of GAD65 antibodies [J].
Dalakas, MC ;
Mian, L ;
Fujii, M ;
Jacobowitz, DM .
NEUROLOGY, 2001, 57 (05) :780-784
[3]   Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies - Study of 14 patients [J].
Honnorat, J ;
Saiz, A ;
Giometto, B ;
Vincent, A ;
Brieva, L ;
de Andres, C ;
Maestre, J ;
Fabien, N ;
Vighetto, A ;
Casamitjana, R ;
Thivolet, C ;
Tavolato, B ;
Antoine, JC ;
Trouillas, P ;
Graus, F .
ARCHIVES OF NEUROLOGY, 2001, 58 (02) :225-230
[4]   Chorea associated with thyroxine replacement therapy [J].
Isaacs, JD ;
Rakshi, J ;
Baker, R ;
Brooks, DJ ;
Warrens, AN .
MOVEMENT DISORDERS, 2005, 20 (12) :1656-1657
[5]   HIGHER AUTOANTIBODY LEVELS AND RECOGNITION OF A LINEAR NH2-TERMINAL EPITOPE IN THE AUTOANTIGEN GAD(65), DISTINGUISH STIFF-MAN SYNDROME FROM INSULIN-DEPENDENT DIABETES-MELLITUS [J].
KIM, J ;
NAMCHUK, M ;
BUGAWAN, T ;
FU, Q ;
JAFFE, M ;
SHI, YG ;
AANSTOOT, HJ ;
TURCK, CW ;
ERLICH, H ;
LENNON, V ;
BAEKKESKOV, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (02) :595-606
[6]   Stiff man syndrome and related conditions [J].
Meinck, HM ;
Thompson, PD .
MOVEMENT DISORDERS, 2002, 17 (05) :853-866
[7]  
Orija Israel B, 2005, Endocr Pract, V11, P259
[8]   Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies [J].
Rakocevic, Goran ;
Raju, Raghavan ;
Semino-Mora, Cristina ;
Dalakas, Marinos C. .
NEUROLOGY, 2006, 67 (06) :1068-1070
[9]   Bilateral chorea-ballism associated with hyperthyroidism [J].
Ristic, AJ ;
Svetel, M ;
Dragasevic, N ;
Zarkovic, M ;
Koprivsek, K ;
Kostic, VS .
MOVEMENT DISORDERS, 2004, 19 (08) :982-983
[10]   AUTOANTIBODIES TO GABAERGIC NEURONS AND PANCREATIC BETA-CELLS IN STIFF-MAN SYNDROME [J].
SOLIMENA, M ;
FOLLI, F ;
APARISI, R ;
POZZA, G ;
DECAMILLI, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (22) :1555-1560
12