Design, synthesis and biological evaluation of novel lipoamino acid-based glycolipids for oral drug delivery

被引：31

作者：

Falconer, Robert A.

Toth, Istvan ^{[1
]}

机构：

[1] Univ Bradford, Sch Life Sci, Inst Canc Therapeut, Bradford BD7 1DP, W Yorkshire, England

[2] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 22期

基金：

英国生物技术与生命科学研究理事会;

关键词：

drug delivery; glycolipid; lipoamino acid; liposaccharide;

D O I：

10.1016/j.bmc.2007.07.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharicles (including glycosy) azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, Sand C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7012 / 7020

页数：9

共 28 条

[1] Caco-2 monolayers in experimental and theoretical predictions of drug transport (Reprinted from Advanced Drug Delivery Reviews, vol 22, pg 67-84, 1996) [J].