Successful Treatment of Systemic Geotrichum capitatum Infection by Liposomal Amphotericin-B, Itraconazole, and Voriconazole in a Japanese Man

被引：25

作者：

Ikuta, Katsuya ^{[1
]}

Torimoto, Yoshihiro ^{[2
]}

Yamamoto, Masayo ^{[1
]}

Okamura, Naoka ^{[1
]}

Hosoki, Takaaki ^{[1
]}

Sato, Kazuya ^{[1
]}

Fujiya, Mikihiro ^{[1
]}

Kohgo, Yutaka ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Med, Div Gastroenterol & Hematol Oncol, Asahikawa, Hokkaido 078, Japan

[2] Asahikawa Med Coll Hosp, Ctr Oncol, Asahikawa, Hokkaido, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 22期

关键词：

Geotrichum capitatum; acure myelogeneous leukemia (AML); amphotericin B; itraconazole; voriconazole; OF-THE-LITERATURE; BLASTOSCHIZOMYCES-CAPITATUS; PATIENT; LEUKEMIA; CASPOFUNGIN;

D O I：

10.2169/internalmedicine.49.3887

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe systemic Geotrichum capitatum (G. capitatum) infection is rare, especially in Japan. G. capitatum infection has been reported mainly in immunocompromised patients and the prognosis is poor with a mortality rate of approximately 50-75%. Here, we report a Japanese case of systemic G. capitatum infection in a severe neutropenic patient who was receiving chemotherapy for acute myelogeneous leukemia with multilineage dysplasia. G. capitatum was isolated from blood cultures, and also formed multiple nodular lesions in lung fields. The infection was successfully cured with a combination of amphotericin B, itraconazole, and voriconazole.

引用

页码：2499 / 2503

页数：5

共 19 条

[1]

Amft N, 1996, HAEMATOLOGICA, V81, P352

[2] Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp. [J].

Bouza, E ;

Muñoz, P .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 :76-85

[3]

Buchta V, 2001, MYCOSES, V44, P505, DOI 10.1046/j.1439-0507.2001.00699.x

[4]

Ersoz G, 2004, JPN J INFECT DIS, V57, P248

[5] Comparison of RapID yeast plus system with API 20C system for identification of common, new, and emerging yeast pathogens [J].

Espinel-Ingroff, A ;

Stockman, L ;

Roberts, G ;

Pincus, D ;

Pollack, J ;

Marler, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (04) :883-886

[6] Successful treatment of disseminated Geotrichum capitatum infection with a combination of caspofungin and voriconazole in an immunocompromised patient [J].

Etienne, A. ;

Datry, A. ;

Gaspar, N. ;

Morel, V. ;

Delabesse, E. ;

Lmimouni, B. ;

Vernant, J. P. ;

Dhedin, N. .

MYCOSES, 2008, 51 (03) :270-272

[7] Fungaemia survey: a 10-year experience in Bergamo, Italy [J].

Farina, C ;

Vailati, F ;

Manisco, A ;

Goglio, A .

MYCOSES, 1999, 42 (9-10) :543-548

[8] Combined voriconazole plus caspofungin therapy for the treatment of probable Geotrichum pneumonia in a leukemia patient [J].

Fianchi, L. ;

Montini, L. ;

Caira, M. ;

Voso, M. T. ;

Maviglia, R. ;

Posteraro, B. ;

Pagano, L. .

INFECTION, 2008, 36 (01) :65-67

[9] Genotyping and antifungal susceptibility profile of Dipodascus capitatus isolates causing disseminated infection in seven hematological patients of a tertiary hospital [J].

Gadea, I ;

Cuenca-Estrella, M ;

Prieto, E ;

Diaz-Guerra, TM ;

Garcia-Cia, JI ;

Mellado, E ;

Tomas, JF ;

Rodriguez-Tudela, JL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (04) :1832-1836

[10]

Girmenia C, 2005, J CLIN MICROBIOL, V43, P1818, DOI 10.1128/JCM.43.4.1818-1828.2005

← 1 2 →