Chronic traumatic encephalopathy (CTE), a disease process well-recognized in boxers, American football players and military personnel, is a progressive neurodegenerative disease caused by repetitive blows to the head. Subjects with CTE can have a wide range of emotional, cognitive and physical symptoms. The cognitive group patients had a significantly higher probability of developing dementia in later years. Currently, there are no disease modifying regimen for CTE. Timely intervention of head blow could diminish the development of CTE. Low-intensity pulsed ultrasound (LIPUS) is a common adjunct used to promote bone healing for fresh fracture. Recent reports suggest that LIPUS can noninvasively modulate the cortical function and have neuroprotective effect in various animal models of traumatic brain injury, stroke, Alzheimer's disease and major depressive disorder. The multifunctional mechanisms of LIPUS neuroprotective effect include several trophic factor stimulations, anti-inflammatory properties and reduction of brain edema. From the above evidence, LIPUS intervention could be a strategy for the prevention of the clinical CTE sequelae of repetitive head blows. We hypothesized that due to its neuroprotective effects, the non-invasive and easy-to-use method of LIPUS brain stimulation could have a preventive effect on players who have head blows during the match. The development of a time sensitive protocol, resembling the therapeutic algorithm for traumatic brain injury, would potentially prevent the development of subsequent CTE adverse outcome. Further long-term longitudinal studies of LIPUS stimulation are warranted to verify the prevention efficacy of this intervention for CTE.
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[Anonymous], 2017, BMJ BRIT MED J, DOI DOI 10.1136/BMJ.J656
机构:
Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Chen, Tao-Tao
Lan, Tsuo-Hung
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Natl Yang Ming Univ, Dept Psychiat, Taipei, Taiwan
Taichung Vet Gen Hosp, Dept Psychiat, Taichung, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Lan, Tsuo-Hung
Yang, Feng-Yi
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Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Natl Yang Ming Univ, Biophoton & Mol Imaging Res Ctr, Taipei, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
机构:
Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Ge, Xintong
Yu, Jinwen
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Yu, Jinwen
Huang, Shan
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Huang, Shan
Yin, Zhenyu
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Yin, Zhenyu
Han, Zhaoli
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Han, Zhaoli
Chen, Fanglian
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Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Chen, Fanglian
Wang, Zengguang
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Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Wang, Zengguang
Zhang, Jianning
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Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Zhang, Jianning
Lei, Ping
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
机构:
Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Hong, Chen-Jee
Liou, Ying-Jay
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Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
机构:
Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Chen, Tao-Tao
Lan, Tsuo-Hung
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机构:
Natl Yang Ming Univ, Dept Psychiat, Taipei, Taiwan
Taichung Vet Gen Hosp, Dept Psychiat, Taichung, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Lan, Tsuo-Hung
Yang, Feng-Yi
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机构:
Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
Natl Yang Ming Univ, Biophoton & Mol Imaging Res Ctr, Taipei, TaiwanNatl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan
机构:
Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Ge, Xintong
Yu, Jinwen
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Yu, Jinwen
Huang, Shan
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Huang, Shan
Yin, Zhenyu
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Yin, Zhenyu
Han, Zhaoli
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Han, Zhaoli
Chen, Fanglian
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机构:
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Chen, Fanglian
Wang, Zengguang
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Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Wang, Zengguang
Zhang, Jianning
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Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Tianjin Neurol Inst, Key Lab Injuries Variat & Regenerat Nervous Syst, Tianjin 300052, Peoples R China
Minist Educ, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
Zhang, Jianning
Lei, Ping
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Tianjin Med Univ Gen Hosp, Tianjin Geriatr Inst, Lab Neurotrauma & Neurodegenerat Disorders, Tianjin 300052, Peoples R China
Tianjin Med Univ Gen Hosp, Dept Geriatr, 154 Anshan Rd, Tianjin 300052, Peoples R ChinaTianjin Med Univ Gen Hosp, Dept Neurosurg, 154 Anshan Rd, Tianjin 300052, Peoples R China
机构:
Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Hong, Chen-Jee
Liou, Ying-Jay
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机构:
Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan