Preventive potential of low intensity pulsed ultrasound for chronic traumatic encephalopathy after repetitive head collisions in contact sports

被引:4
作者
Tsai, Shih-Jen [1 ,2 ,3 ]
机构
[1] Taipei Vet Gen Hosp, Dept Psychiat, 201 Shih Pai Rd,Sec 2, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei, Taiwan
[3] Natl Yang Ming Univ, Brain Res Ctr, Taipei, Taiwan
关键词
Ultrasound; Chronic traumatic encephalopathy; Prevention; Neurotrophic factors; Inflammation; NEUROTROPHIC FACTOR; BRAIN-INJURY; FOOTBALL PLAYER; BIOMARKERS; TAU;
D O I
10.1016/j.mehy.2019.109422
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Chronic traumatic encephalopathy (CTE), a disease process well-recognized in boxers, American football players and military personnel, is a progressive neurodegenerative disease caused by repetitive blows to the head. Subjects with CTE can have a wide range of emotional, cognitive and physical symptoms. The cognitive group patients had a significantly higher probability of developing dementia in later years. Currently, there are no disease modifying regimen for CTE. Timely intervention of head blow could diminish the development of CTE. Low-intensity pulsed ultrasound (LIPUS) is a common adjunct used to promote bone healing for fresh fracture. Recent reports suggest that LIPUS can noninvasively modulate the cortical function and have neuroprotective effect in various animal models of traumatic brain injury, stroke, Alzheimer's disease and major depressive disorder. The multifunctional mechanisms of LIPUS neuroprotective effect include several trophic factor stimulations, anti-inflammatory properties and reduction of brain edema. From the above evidence, LIPUS intervention could be a strategy for the prevention of the clinical CTE sequelae of repetitive head blows. We hypothesized that due to its neuroprotective effects, the non-invasive and easy-to-use method of LIPUS brain stimulation could have a preventive effect on players who have head blows during the match. The development of a time sensitive protocol, resembling the therapeutic algorithm for traumatic brain injury, would potentially prevent the development of subsequent CTE adverse outcome. Further long-term longitudinal studies of LIPUS stimulation are warranted to verify the prevention efficacy of this intervention for CTE.
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页数:3
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共 38 条
  • [1] [Anonymous], 2017, BMJ BRIT MED J, DOI DOI 10.1136/BMJ.J656
  • [2] Busse JW, 2002, CAN MED ASSOC J, V166, P437
  • [3] Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction
    Chen, Chang-Mu
    Wu, Cheng-Tien
    Yang, Ting-Hua
    Liu, Shing-Hwa
    Yang, Feng-Yi
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [4] Low-Intensity Pulsed Ultrasound Attenuates LPS-Induced Neuroinflammation and Memory Impairment by Modulation of TLR4/NF-κB Signaling and CREB/BDNF Expression
    Chen, Tao-Tao
    Lan, Tsuo-Hung
    Yang, Feng-Yi
    [J]. CEREBRAL CORTEX, 2019, 29 (04) : 1430 - 1438
  • [5] Chronic Traumatic Encephalopathy: A Brief Overview
    Fesharaki-Zadeh, Arman
    [J]. FRONTIERS IN NEUROLOGY, 2019, 10
  • [6] A novel repetitive mild traumatic brain injury mouse model for chronic traumatic encephalopathy research
    Ge, Xintong
    Yu, Jinwen
    Huang, Shan
    Yin, Zhenyu
    Han, Zhaoli
    Chen, Fanglian
    Wang, Zengguang
    Zhang, Jianning
    Lei, Ping
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 2018, 308 : 162 - 172
  • [7] DIRECT HITS TO THE HEAD DURING AMATEUR BOXING IS ASSOCIATED WITH A RISE IN SERUM BIOMARKERS FOR BRAIN INJURY
    Graham, M. R.
    Myers, T.
    Evans, P.
    Davies, B.
    Cooper, S. M.
    Bhattacharya, K.
    Grace, F. M.
    Baker, J. S.
    [J]. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2011, 24 (01) : 119 - 125
  • [8] Effects of BDNF polymorphisms on brain function and behavior in health and disease
    Hong, Chen-Jee
    Liou, Ying-Jay
    Tsai, Shih-Jen
    [J]. BRAIN RESEARCH BULLETIN, 2011, 86 (5-6) : 287 - 297
  • [9] Chronic Traumatic Encephalopathy: A Critical Appraisal
    Levin, Benjamin
    Bhardwaj, Anish
    [J]. NEUROCRITICAL CARE, 2014, 20 (02) : 334 - 344
  • [10] Low-intensity (400 mW/cm2, 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats
    Li, Hangdao
    Sun, Junfeng
    Zhang, Daqu
    Omire-Mayor, Daryl
    Lewin, Peter A.
    Tong, Shanbao
    [J]. BRAIN STIMULATION, 2017, 10 (03) : 695 - 702