A three-component solid-phase synthesis of 3-aminoimidazo[1,2-a]azines

被引：125

作者：

Blackburn, C ^{[1
]}

机构：

[1] Millennium Pharmaceut, Drug Discovery, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(98)01113-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three-component condensation between a 2-aminoazine, an aldehyde and an isonitrile catalyzed by scandium triflate was conducted on a solid support with any of the three reacting functional groups tethered to Rink amide resin via an appropriate bifunctional carboxylic acid. The resulting resin-bound 3-aminoimidazo[1,2-a]azines could be efficiently acylated prior to cleavage. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5469 / 5472

页数：4

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