Safinamide as an adjunct therapy in older patients with Parkinson's disease: a retrospective study

被引：5

作者：

Lo Monaco, Maria Rita ^{[1
,2
]}

Petracca, Martina ^{[2
,3
]}

Vetrano, Davide Liborio ^{[1
,4
]}

Di Stasio, Enrico ^{[2
,5
]}

Fusco, Domenico ^{[1
,2
]}

Ricciardi, Diego ^{[2
]}

Laudisio, Alice ^{[6
]}

Zuccala, Giuseppe ^{[1
,2
]}

Onder, Graziano ^{[1
,2
]}

Bentivoglio, Anna Rita ^{[2
,3
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Internal Med & Geriatr, I-00168 Rome, Italy

[2] Fdn Policlin Univ Agostino Gemelli IRCSS, Largo A Gemelli 8, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy

[4] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden

[5] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, I-00168 Rome, Italy

[6] Rome Univ, Unit Geriatr, Dept Med, Campus Biomed, Rome, Italy

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2020年 / 32卷 / 07期

关键词：

Parkinson's disease; Older patients; Safinamide; ADD-ON; LEVODOPA; ONSET;

D O I：

10.1007/s40520-020-01469-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background Safinamide, as a levodopa adjunct, is effective in reducing motor fluctuations in Parkinson's disease (PD) patients; however, scarce evidence is available regarding its use in older PD patients. Aim To evaluate the safety and tolerability of safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD. Methods A retrospective study including 203 PD patients admitted to a geriatric day hospital, who were evaluated following an extensive clinical protocol. Safinamide use was categorized as never used, ongoing, and withdrawn. Potential correlations of Safinamide withdrawal were investigated in stepwise backward logistic regression models. Results A total of 44 out of 203 participants were current or former users of Safinamide. Overall, 14 (32%) patients discontinued due to treatment-emergent adverse events (TEAEs). Withdrawal was not associated with older age. Conclusions Safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD was found to be safe and well-tolerated in older patients. There were no specific demographic or clinical characteristics associated with suspension.

引用

页码：1369 / 1373

页数：5

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