A convenient one-pot synthesis of 1,2-aminoalcohols

被引：1
|
作者：
Howarth, J [1 ]
Lloyd, DG [1 ]
McCormac, P [1 ]
机构：
[1] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland
来源：
SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 15期
关键词：
D O I：
10.1080/00397919808004848
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.
引用
收藏
页码：2751 / 2759
页数：9
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