Cloning of a novel C-type lectin expressed by murine macrophages

被引：64
作者：
Balch, SG
McKnight, AJ
Seldin, MF
Gordon, S
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[2] Univ Calif Davis, Dept Biol Chem, Rowe Program Genet, Davis, CA 95616 USA
[3] Univ Calif Davis, Dept Med, Davis, CA 95616 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 1998年 / 273卷 / 29期
关键词：
D O I：
10.1074/jbc.273.29.18656
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the cloning of a novel macrophage-restricted C-type lectin by differential display polymerase chain reaction. This molecule, named mouse macrophage C-type lectin, is a 219-amino acid, type II transmembrane protein with a single extracellular C-type lectin domain. Northern blot analysis indicates that it is expressed in cell lines and normal mouse tissues in a macrophage-restricted manner. The cDNA and genomic sequences of mouse macrophage C-type lectin indicate that it is related to the Group II animal C-type lectins. The mel gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex.
引用
收藏
页码：18656 / 18664
页数：9
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