Biological features of the clone involved in primary amyloidosis (AL)

被引：12
|
作者：
Perfetti, V
Vignarelli, MC
Casarini, S
Ascari, E
Merlini, G
机构：
[1] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy
[2] Univ Pavia, IRCCS, Policlin S Matteo, Biotechnol Res Labs, I-27100 Pavia, Italy
来源：
LEUKEMIA | 2001年 / 15卷 / 02期
关键词：
primary amyloidosis; AL amyloidosis; plasma cell dyscrasias; B cell lymphoproliferative disorders;
D O I：
10.1038/sj.leu.2402015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). It is the most common form of systemic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for the design and optimization of therapeutic strategies.
引用
收藏
页码：195 / 202
页数：8
相关论文
共 50 条
  • [1] Biological features of the clone involved in primary amyloidosis (AL)
    V Perfetti
    M Colli Vignarelli
    S Casarini
    E Ascari
    G Merlini
    Leukemia, 2001, 15 : 195 - 202
  • [2] PRIMARY (AL) AMYLOIDOSIS
    COHEN, AS
    RENAL FAILURE, 1993, 15 (03) : 429 - 433
  • [3] Primary (AL) amyloidosis
    Merlini, G
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2001, 8 : 54 - 55
  • [4] Incomplete ileus and hemafecia as the presenting features of multi-organ involved primary systemic AL amyloidosis: a rare case report
    Tian, Li
    Tang, Anliu
    Zhang, Xian
    Mei, Zhen
    Liu, Fen
    Li, Jingbo
    Li, Xiayu
    Ai, Feiyan
    Wang, Xiaoyan
    Shen, Shourong
    BMC GASTROENTEROLOGY, 2017, 17
  • [5] Incomplete ileus and hemafecia as the presenting features of multi-organ involved primary systemic AL amyloidosis: a rare case report
    Li Tian
    Anliu Tang
    Xian Zhang
    Zhen Mei
    Fen Liu
    Jingbo Li
    Xiayu Li
    Feiyan Ai
    Xiaoyan Wang
    Shourong Shen
    BMC Gastroenterology, 17
  • [6] Primary (AL) hepatic amyloidosis - Clinical features and natural history in 98 patients
    Park, MA
    Mueller, PS
    Kyle, RA
    Larson, DR
    Plevak, MF
    Gertz, MA
    MEDICINE, 2003, 82 (05) : 291 - 298
  • [7] DIMETHYLSULFOXIDE IN PRIMARY AL AMYLOIDOSIS
    CROVATO, F
    DEMARCHI, R
    NAZZARI, G
    DESIRELLO, G
    FUSCO, F
    HAEMATOLOGICA, 1984, 69 (02) : 234 - 235
  • [8] PRIMARY AMYLOIDOSIS (AL) IN FAMILIES
    GERTZ, MA
    GARTON, JP
    KYLE, RA
    AMERICAN JOURNAL OF HEMATOLOGY, 1986, 22 (02) : 193 - 198
  • [9] Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis.
    Lachmann, HJ
    Booth, DR
    Booth, SE
    Bybee, A
    Gilbertson, JA
    Gillmore, JD
    Pepys, MB
    Hawkins, PN
    NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (23): : 1786 - 1791
  • [10] Amyloidosis of pancreatic islets in primary amyloidosis (AL type)
    Tomita, T
    PATHOLOGY INTERNATIONAL, 2005, 55 (04) : 223 - 227
12345