Straightforward Method for the Synthesis of Selenocysteine and Selenocystine Derivatives from L-Serine Methyl Ester

被引：19

作者：

Braga, Antonio L. ^{[1
]}

Wessjohann, Ludger A. ^{[2
]}

Taube, Paulo S. ^{[1
]}

Galetto, Fabio Z. ^{[1
,3
]}

de Andrade, Fabiano M. ^{[3
]}

机构：

[1] Univ Fed Santa Catarina, Dept Quim, BR-88040970 Florianopolis, SC, Brazil

[2] Leibniz Inst Plant Biochem, D-06120 Halle, Germany

[3] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

SYNTHESIS-STUTTGART | 2010年 / 18期

关键词：

organoselenium; selenoamino acids; selenocysteine; selenocystine; tellurocysteine; CONTAINING AMINO-ACIDS; RING-OPENING REACTION; BETA-SELENO AMIDES; EFFICIENT SYNTHESIS; ORGANOSELENIUM; THIOREDOXIN; CHEMISTRY; SULFUR; SE; PHENYLSELENOALANINE;

D O I：

10.1055/s-0030-1258188

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A set of selenoamino acids has been efficiently synthesized under smooth conditions by a simple, flexible and modular strategy. In this method, O-mesylated L-serine methyl ester is generated in situ and directly substituted with various selenolate anions to afford selenocysteine, selenolanthionine, and selenocystine derivatives in good yields. Also, a tellurocysteine derivative can be obtained by this method.

引用

页码：3131 / 3137

页数：7

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