Tissue-based genomics: which test and when

被引:5
作者
Vince, Randy A., Jr. [1 ]
Tosoian, Jeffrey J. [1 ]
Jackson, William C. [2 ]
Spratt, Daniel E. [2 ]
Morgan, Todd M. [1 ]
机构
[1] Univ Michigan, Dept Urol, Michigan Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Radiat Oncol, Michigan Med, Ann Arbor, MI 48109 USA
关键词
active surveillance; adjuvant; genomics; prostatic neoplasms; radical prostatectomy; radiotherapy; salvage; RISK PROSTATE-CANCER; CYCLE PROGRESSION SCORE; TERM-FOLLOW-UP; RADICAL PROSTATECTOMY; ACTIVE SURVEILLANCE; ADJUVANT RADIATION; POSTOPERATIVE RADIOTHERAPY; DECISION-MAKING; VALIDATION; CLASSIFIER;
D O I
10.1097/MOU.0000000000000673
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review The clinical course of localized prostate cancer varies widely, ranging from indolent disease unlikely to require treatment to aggressive cancers meriting intensive, multimodal therapy. Management recommendations have traditionally been determined based on clinical and pathologic factors, including serum prostate - specific antigen (PSA), clinical stage, and Gleason score. Unfortunately, these factors have limited ability to describe the underlying biology of a given tumor. Tissue-based genomic tests have emerged as a promising tool to more accurately characterize prostate cancer biology and projected clinical course. The current review article summarizes available data describing the clinical use of genomic assays, with a specific focus on three critical scenarios. Recent findings We reviewed the potential role of tissue-based genomic assays in determining: the appropriateness of active surveillance versus definitive therapy, patients that will benefit from adjuvant radiation therapy following radical prostatectomy, and men most likely to benefit from concurrent androgen deprivation therapy with primary radiotherapy. Current literature suggests that commercially available genomic tests provide prognostic information independent of traditional risk factors that may augment clinical decision-making. Additional data will better clarify the optimal use of each test across common clinical scenarios.
引用
收藏
页码:598 / 604
页数:7
相关论文
共 48 条
[1]   Evolving transcriptomic fingerprint based on genome-wide data as prognostic tools in prostate cancer [J].
Alshalalfa, Mohammed ;
Schliekelman, Mark ;
Shin, Heesun ;
Erho, Nicholas ;
Davicioni, Elai .
BIOLOGY OF THE CELL, 2015, 107 (07) :232-244
[2]   The Development of Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) [J].
Andren, Ove ;
Armstrong, John ;
Berry, Donald ;
Bolla, Michel ;
Buyse, Marc ;
Chowdhury, Simon ;
Clarke, Noel ;
Collette, Laurence ;
Cooperberg, Matthew ;
Denham, Jim ;
Eisenberger, Mario ;
Dignam, James ;
Fizazi, Karim ;
Freidlin, Boris ;
Gleave, Martin ;
Habibian, Muriel ;
Halabi, Susan ;
Hayes, Julia ;
James, Nick ;
Jarow, Jonathan ;
Keating, Nancy ;
Kantoff, Philip ;
Kelloff, Gary ;
Klotz, Laurence ;
Li, Suhui ;
Lukka, Himu ;
Mahal, Brandon ;
Mason, Malcolm ;
Miyahara, Andrea ;
Nakabayashi, Mari ;
Parulekar, Wendy ;
Philipson, Tomas ;
Regan, Meredith ;
Sandler, Howard ;
Sartor, Oliver ;
Scardino, Peter ;
Scher, Howard ;
Simon, Richard ;
Simons, Jonathan ;
Small, Eric ;
Soule, Howard ;
Sweeney, Christopher ;
Sydes, Matthew ;
Tangen, Catherine ;
Thompson, Ian ;
Tombal, Bertrand ;
Widmark, Anders ;
Wiegel, Thomas ;
Williams, Scott ;
Xie, Wanling .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2015, 107 (12)
[3]   Genomic Classifier for Guiding Treatment of Intermediate-Risk Prostate Cancers to Dose-Escalated Image Guided Radiation Therapy Without Hormone Therapy [J].
Berlin, Alejandro ;
Murgic, Jure ;
Hosni, Ali ;
Pintilie, Melania ;
Salcedo, Adriana ;
Fraser, Michael ;
Kamel-Reid, Suzanne ;
Zhang, Jingbin ;
Wang, Qiqi ;
Ch'ng, Carolyn ;
Deheshi, Samineh ;
Davicioni, Elai ;
van der Kwast, Theodorus ;
Boutros, Paul C. ;
Bristow, Robert G. ;
Chua, Melvin L. K. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 103 (01) :84-91
[4]   Prognostic Utility of the Cell Cycle Progression Score Generated from Biopsy in Men Treated with Prostatectomy [J].
Bishoff, Jay T. ;
Freedland, Stephen J. ;
Gerber, Leah ;
Tennstedt, Pierre ;
Reid, Julia ;
Welbourn, William ;
Graefen, Markus ;
Sangale, Zaina ;
Tikishvili, Eliso ;
Park, Jimmy ;
Younus, Adib ;
Gutin, Alexander ;
Lanchbury, Jerry S. ;
Sauter, Guido ;
Brawer, Michael ;
Stone, Steven ;
Schlomm, Thorsten .
JOURNAL OF UROLOGY, 2014, 192 (02) :409-414
[5]   Development and Clinical Validation of an In Situ Biopsy-Based Multimarker Assay for Risk Stratification in Prostate Cancer [J].
Blume-Jensen, Peter ;
Berman, David M. ;
Rimm, David L. ;
Shipitsin, Michail ;
Putzi, Mathew ;
Nifong, Thomas P. ;
Small, Clayton ;
Choudhury, Sibgat ;
Capela, Teresa ;
Coupal, Louis ;
Ernst, Christina ;
Hurley, Aeron ;
Kaprelyants, Alex ;
Chang, Hua ;
Giladi, Eldar ;
Nardone, Julie ;
Dunyak, James ;
Loda, Massimo ;
Klein, Eric A. ;
Magi-Galluzzi, Cristina ;
Latour, Mathieu ;
Epstein, Jonathan I. ;
Kantoff, Philip ;
Saad, Fred .
CLINICAL CANCER RESEARCH, 2015, 21 (11) :2591-2600
[6]   Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911) [J].
Bolla, Michel ;
van Poppel, Hein ;
Tombal, Bertrand ;
Vekemans, Kris ;
Da Pozzo, Luigi ;
de Reijke, Theo M. ;
Verbaeys, Antony ;
Bosset, Jean-Francois ;
van Velthoven, Roland ;
Colombel, Marc ;
van de Beek, Cees ;
Verhagen, Paul ;
van den Bergh, Alphonsus ;
Sternberg, Cora ;
Gasser, Thomas ;
van Tienhoven, Geertjan ;
Scalliet, Pierre ;
Haustermans, Karin ;
Collette, Laurence .
LANCET, 2012, 380 (9858) :2018-2027
[7]   70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer [J].
Cardoso, F. ;
van't Veer, L. J. ;
Bogaerts, J. ;
Slaets, L. ;
Viale, G. ;
Delaloge, S. ;
Pierga, J. -Y. ;
Brain, E. ;
Causeret, S. ;
DeLorenzi, M. ;
Glas, A. M. ;
Golfinopoulos, V. ;
Goulioti, T. ;
Knox, S. ;
Matos, E. ;
Meulemans, B. ;
Neijenhuis, P. A. ;
Nitz, U. ;
Passalacqua, R. ;
Ravdin, P. ;
Rubio, I. T. ;
Saghatchian, M. ;
Smilde, T. J. ;
Sotiriou, C. ;
Stork, L. ;
Straehle, C. ;
Thomas, G. ;
Thompson, A. M. ;
van der Hoeven, J. M. ;
Vuylsteke, P. ;
Bernards, R. ;
Tryfonidis, K. ;
Rutgers, E. ;
Piccart, M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (08) :717-729
[8]   Validation of a Cell-Cycle Progression Gene Panel to Improve Risk Stratification in a Contemporary Prostatectomy Cohort [J].
Cooperberg, Matthew R. ;
Simko, Jeffry P. ;
Cowan, Janet E. ;
Reid, Julia E. ;
Djalilvand, Azita ;
Bhatnagar, Satish ;
Gutin, Alexander ;
Lanchbury, Jerry S. ;
Swanson, Gregory P. ;
Stone, Steven ;
Carroll, Peter R. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (11) :1428-1434
[9]   Risk Assessment for Prostate Cancer Metastasis and Mortality at the Time of Diagnosis [J].
Cooperberg, Matthew R. ;
Broering, Jeanette M. ;
Carroll, Peter R. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (12) :878-887
[10]   A Biopsy-based 17-gene Genomic Prostate Score Predicts Recurrence After Radical Prostatectomy and Adverse Surgical Pathology in a Racially Diverse Population of Men with Clinically Low- and Intermediate-risk Prostate Cancer [J].
Cullen, Jennifer ;
Rosner, Inger L. ;
Brand, Timothy C. ;
Zhang, Nan ;
Tsiatis, Athanasios C. ;
Moncur, Joel ;
Ali, Amina ;
Chen, Yongmei ;
Knezevic, Dejan ;
Maddala, Tara ;
Lawrence, H. Jeffrey ;
Febbo, Phillip G. ;
Srivastava, Shiv ;
Sesterhenn, Isabell A. ;
McLeod, David G. .
EUROPEAN UROLOGY, 2015, 68 (01) :123-131