Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children

被引：16

作者：

Amre, Devendra K. ^{[1
,2
]}

Mack, David R. ^{[3
]}

Morgan, Kenneth ^{[4
,5
]}

Israel, David ^{[9
]}

Deslandres, Colette ^{[1
,2
]}

Seidman, Ernest G. ^{[4
,10
]}

Lambrette, Phlippe ^{[1
]}

Costea, Irina ^{[1
]}

Krupoves, Alfreda ^{[1
,8
]}

Fegury, Houda ^{[1
]}

Dong, Jinsong ^{[1
]}

Xhu, Zia ^{[1
]}

Grimard, Guy ^{[1
,7
]}

Levy, Emile ^{[1
,6
]}

机构：

[1] St Justine Hosp, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Dept Pediat, Montreal, PQ H3C 3J7, Canada

[3] Childrens Hosp Eastern Ontario, Div Gastroenterol Hepatol & Nutr, Ottawa, ON K1H 8L1, Canada

[4] McGill Univ, Res Inst, Ctr Hlth, Montreal, PQ, Canada

[5] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[6] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada

[7] Univ Montreal, Dept Pediat, Div Orthoped, Montreal, PQ H3C 3J7, Canada

[8] Univ Montreal, Dept Prevent & Social Med, Montreal, PQ H3C 3J7, Canada

[9] British Columbia Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, Vancouver, BC, Canada

[10] McGill Univ, Fac Med, Div Gastroenterol, Montreal, PQ, Canada

来源：

HUMAN GENETICS | 2010年 / 128卷 / 02期

基金：

加拿大健康研究院;

关键词：

INFLAMMATORY-BOWEL-DISEASE; LOCI; VARIANTS; GENE; SUSCEPTIBILITY; CHILDHOOD; 21Q22; 20Q13;

D O I：

10.1007/s00439-010-0835-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn' disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated with CD in Canadian children. A case-control design was implemented at three pediatric gastroenterology clinics in Canada. Children < 19 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in 19 reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. A total of 563 cases and 553 controls were studied. The mean (+/- SD) age of the cases was 12.3 (+/- 3.2) years. Most cases were male (56.0%), had ileo-colonic disease (L3 +/- A L4, 48.8%) and inflammatory behavior (B1 +/- A p, 87.9%) at diagnosis. Allelic association analysis (two-tailed) showed that 8 of the 19 targeted SNPs were significantly associated with overall susceptibility for CD. Associations with one additional SNP was borderline non-significant. Significantly associated SNPs included SNPs rs1250550 (p = 0.026) and rs8049439 (p = 0.04), recently reported to be specifically associated with pediatric-onset CD.Based on the results, we confirmed associations between two of the three novel pediatric-CD loci and other regions reported for associations with either pediatric and/or adult-onset CD.

引用

页码：131 / 135

页数：5

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