Bioinspired Zinc Oxide Nanoparticles Using Lycopersicon esculentum for Antimicrobial and Anticancer Applications

被引：64

作者：

Vijayakumar, Sekar ^{[1
]}

Vaseeharan, Baskaralingam ^{[1
]}

Sudhakaran, Raja ^{[2
]}

Jeyakandan, Jeyaraman ^{[3
]}

Ramasamy, Palaniappan ^{[4
]}

Sonawane, Avinash ^{[5
]}

Padhi, Avinash ^{[5
]}

Velusamy, Palaniyandi ^{[6
]}

Anbu, Periasamy ^{[7
]}

Faggio, Caterina ^{[8
]}

机构：

[1] Alagappa Univ, Dept Anim Hlth & Management, Nanobiosci & Nanopharmacol Div, Biomat & Biotechnol Anim Hlth Lab, Sci Campus 6th Floor, Karaikkudi 630004, Tamil Nadu, India

[2] VIT Univ, Aquaculture Biotechnol Lab, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India

[3] Alagappa Univ, Struct Biol & Biocomp Lab, Dept Bioinformat, Sci Campus 4th Floor, Karaikkudi 630004, Tamil Nadu, India

[4] Bharath Univ, Sree Balaji Med Coll & Hosp, R&D Wing, Chennai 600044, Tamil Nadu, India

[5] KIIT Univ, Sch Biotechnol, Bhubaneswar, Orissa, India

[6] SRM Inst Sci & Technol, Sch Bioengn, Dept Biotechnol, Kancheepuram 603203, Tamil Nadu, India

[7] Inha Univ, Dept Biol Engn, Incheon 402751, South Korea

[8] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno Alcontres 31, I-98166 Sant Agata Di Messina, Italy

来源：

JOURNAL OF CLUSTER SCIENCE | 2019年 / 30卷 / 06期

关键词：

Lycopersicon esculentum; Zinc oxide nanoparticle; Clinical pathogens; Anticoagulant; Antibiofilm; Cytotoxicity; SILVER NANOPARTICLES; IN-VITRO; TOMATO EXTRACT; ZNO; ANTIBACTERIAL; NANOCOMPOSITE; ANTIBIOFILM; CANCER; GOLD; EPIDEMIOLOGY;

D O I：

10.1007/s10876-019-01590-z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lycopersicon esculentum leaf-extract was utilized in the synthesis of zinc-oxide nanoparticles (Le-ZnO-NPs) using zinc acetate as the precursor. The synthesized ZnO-NPs were attested by the detection of a notable absorption peak at 343 nm, appearing in UV-Vis spectra due to surface-plasmon-resonance. The XRD-spectrum recorded at 2 theta values coincides with that of lattice planes. HR-TEM results revealed that Le-ZnO-NPs exhibited a crystalline structure with hexagonal wurtzite shape (10-50 nm size). The effectiveness of inhibition of the microbial biofilms of Proteus vulgaris, Enterococcus faecalis and Candida albicans was analyzed at a concentration of 100 mu g ml(-1). Moreover, Le-ZnO-NPs showed a significant range of anti-coagulant activity, in contrast to commercial anti-coagulant (heparin). Cytotoxicity studies showed that Le-ZnO-NPs (100 mu g ml(-1)) are non-toxic to murine macrophage cells, but toxic to human cervical cancer (HeLa) cells. Indeed, a reduction in the viability of HeLa-cells and a notable variation in the apoptotic cell structure were apparent.

引用

页码：1465 / 1479

页数：15

共 59 条

[11] Zinc oxide nanoparticles as novel alpha-amylase inhibitors [J].