Dental-Derived Mesenchymal Stem Cells: State of the Art

被引：58
作者：
Li, Bo [1 ,2 ,3 ]
Ouchi, Takehito [4 ,5 ]
Cao, Yubin [1 ,2 ,6 ]
Zhao, Zhihe [1 ,2 ,3 ]
Men, Yi [1 ,2 ,6 ]
机构：
[1] Sichuan Univ, West China Sch Stomatol, State Key Lab Oral Dis, Chengdu, Peoples R China
[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, West China Sch Stomatol, Chengdu, Peoples R China
[3] Sichuan Univ, West China Sch Stomatol, Dept Orthodont, Chengdu, Peoples R China
[4] Keio Univ, Sch Med, Dept Dent & Oral Surg, Tokyo, Japan
[5] Tokyo Dent Coll, Dept Physiol, Tokyo, Japan
[6] Sichuan Univ, West China Sch Stomatol, Dept Head & Neck Oncol, Chengdu, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金：
中国国家自然科学基金;
关键词：
mesenchymal stem cells; tooth regeneration; tissue engineering; bone defect reconstruction; immune modulation; PROMOTES OSTEOGENIC DIFFERENTIATION; EXFOLIATED DECIDUOUS TEETH; FIBROBLAST-GROWTH-FACTOR; LONG NONCODING RNA; PULP STEM; PERIODONTAL-LIGAMENT; IN-VITRO; BONE-MARROW; IMMUNOMODULATORY PROPERTIES; MULTIPLE-SCLEROSIS;
D O I：
10.3389/fcell.2021.654559
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mesenchymal stem cells (MSCs) could be identified in mammalian teeth. Currently, dental-derived MSCs (DMSCs) has become a collective term for all the MSCs isolated from dental pulp, periodontal ligament, dental follicle, apical papilla, and even gingiva. These DMSCs possess similar multipotent potential as bone marrow-derived MSCs, including differentiation into cells that have the characteristics of odontoblasts, cementoblasts, osteoblasts, chondrocytes, myocytes, epithelial cells, neural cells, hepatocytes, and adipocytes. Besides, DMSCs also have powerful immunomodulatory functions, which enable them to orchestrate the surrounding immune microenvironment. These properties enable DMSCs to have a promising approach in injury repair, tissue regeneration, and treatment of various diseases. This review outlines the most recent advances in DMSCs' functions and applications and enlightens how these advances are paving the path for DMSC-based therapies.
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页数：19
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