共 205 条
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus
被引:572
作者:

Johansen, Matt D.
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机构:
Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France

Herrmann, Jean-Louis
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机构:
Univ Paris Saclay, UVSQ, INSERM, Infect & Inflammat, Montigny Le Bretonneux, France
Hop Raymond Poincare, AP HP, GHU Paris Saclay, Garches, France Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France

Kremer, Laurent
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机构:
Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France
Inst Rech Infectiol Montpellier, INSERM, Montpellier, France Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France
机构:
[1] Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France
[2] Univ Paris Saclay, UVSQ, INSERM, Infect & Inflammat, Montigny Le Bretonneux, France
[3] Hop Raymond Poincare, AP HP, GHU Paris Saclay, Garches, France
[4] Inst Rech Infectiol Montpellier, INSERM, Montpellier, France
关键词:
16S RIBOSOMAL-RNA;
MYCOLIC ACID TRANSPORT;
TUMOR-NECROSIS-FACTOR;
CYSTIC-FIBROSIS;
CELL-WALL;
TREATMENT OUTCOMES;
AVIUM COMPLEX;
IN-VIVO;
MOLECULAR EPIDEMIOLOGY;
RESISTANCE MUTATIONS;
D O I:
10.1038/s41579-020-0331-1
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Infections caused by non-tuberculous mycobacteria (NTM) are increasing globally and are notoriously difficult to treat due to intrinsic resistance of these bacteria to many common antibiotics. NTM are diverse and ubiquitous in the environment, with only a few species causing serious and often opportunistic infections in humans, including Mycobacterium abscessus. This rapidly growing mycobacterium is one of the most commonly identified NTM species responsible for severe respiratory, skin and mucosal infections in humans. It is often regarded as one of the most antibiotic-resistant mycobacteria, leaving us with few therapeutic options. In this Review, we cover the proposed infection process of M. abscessus, its virulence factors and host interactions and highlight the commonalities and differences of M. abscessus with other NTM species. Finally, we discuss drug resistance mechanisms and future therapeutic options. Taken together, this knowledge is essential to further our understanding of this overlooked and neglected global threat. Non-tuberculous mycobacteria, such as Mycobacterium abscessus, are an increasing global health burden, in part due their extensive drug resistance. In this Review, Johansen, Herrmann and Kremer discuss the infection process, host interactions, mechanisms of drug resistance and drug development.
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页码:392 / 407
页数:16
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