Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus

被引:572
作者
Johansen, Matt D. [1 ]
Herrmann, Jean-Louis [2 ,3 ]
Kremer, Laurent [1 ,4 ]
机构
[1] Univ Montpellier, Inst Rech Infectiol Montpellier, CNRS, UMR 9004, Montpellier, France
[2] Univ Paris Saclay, UVSQ, INSERM, Infect & Inflammat, Montigny Le Bretonneux, France
[3] Hop Raymond Poincare, AP HP, GHU Paris Saclay, Garches, France
[4] Inst Rech Infectiol Montpellier, INSERM, Montpellier, France
关键词
16S RIBOSOMAL-RNA; MYCOLIC ACID TRANSPORT; TUMOR-NECROSIS-FACTOR; CYSTIC-FIBROSIS; CELL-WALL; TREATMENT OUTCOMES; AVIUM COMPLEX; IN-VIVO; MOLECULAR EPIDEMIOLOGY; RESISTANCE MUTATIONS;
D O I
10.1038/s41579-020-0331-1
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Infections caused by non-tuberculous mycobacteria (NTM) are increasing globally and are notoriously difficult to treat due to intrinsic resistance of these bacteria to many common antibiotics. NTM are diverse and ubiquitous in the environment, with only a few species causing serious and often opportunistic infections in humans, including Mycobacterium abscessus. This rapidly growing mycobacterium is one of the most commonly identified NTM species responsible for severe respiratory, skin and mucosal infections in humans. It is often regarded as one of the most antibiotic-resistant mycobacteria, leaving us with few therapeutic options. In this Review, we cover the proposed infection process of M. abscessus, its virulence factors and host interactions and highlight the commonalities and differences of M. abscessus with other NTM species. Finally, we discuss drug resistance mechanisms and future therapeutic options. Taken together, this knowledge is essential to further our understanding of this overlooked and neglected global threat. Non-tuberculous mycobacteria, such as Mycobacterium abscessus, are an increasing global health burden, in part due their extensive drug resistance. In this Review, Johansen, Herrmann and Kremer discuss the infection process, host interactions, mechanisms of drug resistance and drug development.
引用
收藏
页码:392 / 407
页数:16
相关论文
共 205 条
[1]   The ESX-5 Secretion System of Mycobacterium marinum Modulates the Macrophage Response [J].
Abdallah, M. Abdallah ;
Savage, Nigel D. L. ;
van Zon, Maaike ;
Wilson, Louis ;
Vandenbroucke-Grauls, Christina M. J. E. ;
van der Wel, Nicole N. ;
Ottenhoff, Tom H. M. ;
Bitter, Wilbert .
JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :7166-7175
[2]   Type VII secretion - mycobacteria show the way [J].
Abdallah, M. Abdallah ;
Gey Van Pittius, Nicolaas C. ;
Champion, Patricia A. DiGiuseppe ;
Cox, Jeffery ;
Luirink, Joen ;
Vandenbroucke-Grauls, Christina M. J. E. ;
Appelmelk, Ben J. ;
Bitter, Wilbert .
NATURE REVIEWS MICROBIOLOGY, 2007, 5 (11) :883-891
[3]   rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp nov., Mycobacterium phocaicum sp nov and Mycobacterium aubagnense sp nov. [J].
Adékambi, T ;
Berger, P ;
Raoult, D ;
Drancourt, M .
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2006, 56 :133-143
[4]   Amoebal coculture of "Mycobacterium massiliense" sp nov from the sputum of a patient with hemoptoic pneumonia [J].
Adékambi, T ;
Gaubert, MR ;
Greub, G ;
Gevaudan, MJ ;
La Scola, B ;
Raoult, D ;
Drancourt, M .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (12) :5493-5501
[5]   Dissection of phylogenetic relationships among 19 rapidly growing Mycobacterium species by 16S rRNA, hsp65, sodA, recA and rpoB gene sequencing [J].
Adékambi, T ;
Drancourt, M .
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2004, 54 :2095-2105
[6]   Prevalence of Nontuberculous Mycobacterial Lung Disease in US Medicare Beneficiaries [J].
Adjemian, Jennifer ;
Olivier, Kenneth N. ;
Seitz, Amy E. ;
Holland, Steven M. ;
Prevots, D. Rebecca .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 185 (08) :881-886
[7]   Surface spreading motility shown by a group of phylogenetically related, rapidly growing pigmented mycobacteria suggests that motility is a common property of mycobacterial species but is restricted to smooth colonies [J].
Agusti, Gemma ;
Astola, Oihane ;
Rodriguez-Gueell, Elisabeth ;
Julian, Esther ;
Luquin, Marina .
JOURNAL OF BACTERIOLOGY, 2008, 190 (20) :6894-6902
[8]   Role of embB in natural and acquired resistance to ethambutol in mycobacteria [J].
Alcaide, F ;
Pfyffer, GE ;
Telenti, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2270-2273
[9]   Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease [J].
Alexander, David C. ;
Vasireddy, Ravikiran ;
Vasireddy, Sruthi ;
Philley, Julie V. ;
Brown-Elliott, Barbara A. ;
Perry, Benjamin J. ;
Griffith, David E. ;
Benwill, Jeana L. ;
Cameron, Andrew D. S. ;
Wallace, Richard J., Jr. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2017, 55 (02) :574-584
[10]   Molecular identification of potential pathogens in water and air of a hospital therapy pool [J].
Angenent, LT ;
Kelley, ST ;
St Amand, A ;
Pace, NR ;
Hernandez, MT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (13) :4860-4865