Overexpression of sterol 12α-hydroxylase (CYP8b1):: Effect on rates of cholic acid (CA) synthesis and alteration in bile acid pool composition.

被引：0
|
作者：
Pandak, WM
Hylemon, PB
Bohdan, P
Bjorkhem, I
Eggertsen, G
Vlahcevic, ZR
机构：
[1] McGuire Dept Vet Affairs Med Ctr, Richmond, VA USA
[2] Virginia Commonwealth Univ, Richmond, VA USA
[3] Karolinska Inst, Stockholm, Sweden
来源：
GASTROENTEROLOGY | 2001年 / 120卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1
引用
收藏
页码：A1 / A1
页数：1
相关论文
共 39 条
  • [31] Postprandial response and tissue distribution of the bile acid synthesis-related genes, cyp7a1, cyp8b1 and shp, in rainbow trout Oncorhynchus mykiss
    Murashita, Koji
    Yoshiura, Yasutoshi
    Chisada, Shin-ichi
    Furuita, Hirofumi
    Sugita, Tsuyoshi
    Matsunari, Hiroyuki
    Yamamoto, Takeshi
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2013, 166 (02): : 361 - 369
  • [32] On the mechanism of bile acid inhibition of rat sterol 12[alpha]-hydroxylase gene (CYP8B1) transcription by nuclear receptors, [alpha]-fetoprotein transcription factor (FTF) and hepatocyte nuclear receptor 4[alpha] (HNF4[alpha])
    Chiang, JYL
    Yang, Y
    Zhang, M
    Eggertsen, G
    FASEB JOURNAL, 2002, 16 (04): : A562 - A563
  • [33] Structure and chromosomal assignment of the sterol 12α-hydroxylase gene (CYP8B1) in human and mouse:: Eukaryotic cytochrome P-450 gene devoid of introns
    Gåfvels, M
    Olin, M
    Chowdhary, BP
    Raudsepp, T
    Andersson, U
    Persson, B
    Jansson, M
    Björkhem, I
    Eggertsen, G
    GENOMICS, 1999, 56 (02) : 184 - 196
  • [34] Hepatocyte nuclear factor 4α (HNF4α) plays important roles in transcriptional regulation of human sterol 12α-hydroxylase (CYP8B1) gene by bile acids and circadian rhythm.
    Ming, Z
    Chiang, JY
    HEPATOLOGY, 2002, 36 (04) : 241A - 241A
  • [35] Mice Lacking Cyp8b1 Have Dramatically Improved Cardio-Metabolic Profile Due to Alterations in Bile Acid Profile
    Parathath, Saj
    Rosa, Raymond
    Gorski, Judith N.
    Wang, Sheng-ping
    Schlessinger, Karni
    Herath, Kithsiri
    Previs, Stephen
    Castro-Perez, Jose M.
    Wong, Kenny K.
    CIRCULATION, 2014, 130
  • [36] EVIDENCE FOR CARRIER PROTEINS IN BILE-ACID SYNTHESIS - EFFECT OF SQUALENE AND STEROL CARRIER PROTEIN AND ALBUMIN ON ACTIVITY OF 12-ALPHA-HYDROXYLASE
    GRABOWSKI, GA
    MCCOY, KE
    WILLIAMS, GC
    DEMPSEY, ME
    HANSON, RF
    BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 441 (03) : 380 - 390
  • [37] Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes
    Miao, Ji
    Choi, Sung-E
    Seok, Sun Mi
    Yang, Linda
    Zuercher, William J.
    Xu, Yong
    Willson, Timothy M.
    Xu, H. Eric
    Kemper, Jongsook Kim
    MOLECULAR ENDOCRINOLOGY, 2011, 25 (07) : 1159 - 1169
  • [38] Quercetin-Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling
    Liu, Jiaqi
    Liu, Youhua
    Huang, Chaoqun
    He, Chuan
    Yang, Tongyudan
    Ren, Ruiti
    Xin, Zimeng
    Wang, Xinxia
    ADVANCED SCIENCE, 2025,
  • [39] Cholesterol 7α-hydroxylase (CYP7A) gene knockout results in hypercholesterolemia, gender-specific alteration in bile acid pool size and composition and in gender-specific hyperinsulinemia.
    Erickson, SK
    Lear, SR
    Batta, AK
    Shefer, S
    Blanche, PJ
    Salen, G
    Krauss, RM
    HEPATOLOGY, 1999, 30 (04) : 319A - 319A
1234