SYNTHESIS AND GROWTH-STIMULATING ACTIVITY OF 15β-SUBSTITUTED BRASSINOSTEROIDS

被引：1

作者：

Baranovskii, A. V. ^{[1
]}

Popova, M. P. ^{[1
]}

Khripach, V. A. ^{[1
]}

机构：

[1] Natl Acad Sci Belarus, Inst Bioorgan Chem, Minsk 220141, BELARUS

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2015年 / 51卷 / 02期

关键词：

steroids; brassinosteroids; phytohormones; NMR; bioactivity; BIOLOGICAL EVALUATION; BRASSINOLIDE;

D O I：

10.1007/s10600-015-1263-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

15 beta-Hydroxybutylcastasterone and its 24-epimer were synthesized from (20S)-15 beta-(4-benzoyloxybutyl)-20-hydroxymethyl-2 alpha,3 alpha-isopropylidenedioxy-6,6-ethylenedioxy-5 alpha-pregn-16-ene using a sequence of transformations including hydrogenation of the double bond by H-2 over Adams' catalyst, oxidation by Dess-Martin reagent, Julia olefination, Sharpless catalytic dihydroxylation, and hydrolysis of protecting groups. The compounds exhibited activity in growth-stimulating tests that was comparable with those of castasterone and 24-epicastasterone.

引用

页码：289 / 295

页数：7

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