Follicular thyroid carcinoma

被引：104
作者：
Sobrinho-Simoes, Manuel [1 ,2 ,3 ]
Eloy, Catarina [1 ,3 ,4 ]
Magalhaes, Joao [1 ,2 ,3 ]
Lobo, Claudia [5 ]
Amaro, Teresina [5 ]
机构：
[1] Univ Porto, Inst Mol Pathol & Immunol, IPATIMUP, P-4200465 Oporto, Portugal
[2] Univ Porto, Dept Pathol, Fac Med, P-4200465 Oporto, Portugal
[3] Hosp Sao Joao, Dept Pathol, Oporto, Portugal
[4] Univ Porto, Fac Dent, Dept Pathol, P-4200465 Oporto, Portugal
[5] Portuguese Inst Oncol Francisco Gentil, Dept Pathol, Oporto, Portugal
来源：
MODERN PATHOLOGY | 2011年 / 24卷
关键词：
diagnosis; follicular thyroid carcinoma; molecular biomarkers; prognosis; HURTHLE CELL TUMORS; PAPILLARY CARCINOMA; POINT MUTATIONS; PAX8-PPAR-GAMMA REARRANGEMENT; MOLECULAR PATHOLOGY; DIAGNOSTIC-CRITERIA; SOMATIC MUTATIONS; BRAF MUTATIONS; GENOME-WIDE; VARIANT;
D O I：
10.1038/modpathol.2010.133
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Follicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well-differentiated thyroid carcinomas everywhere. This review will discuss the reasons underlying such an observation focusing on the evolution of the morphological and immunohistochemical diagnostic criteria of follicular thyroid tumors. It will address the differential diagnosis between follicular carcinoma and three tumor types-follicular adenoma, follicular variant of papillary carcinoma and poorly differentiated carcinoma-as well as the problems raised by the newly described categories of follicular tumors: follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential and well-differentiated carcinoma, not otherwise specified. Finally, the prognostic and therapeutic significance of some promising molecular biomarkers will be discussed within the frame of the aforementioned histopathological classification. Modern Pathology (2011) 24, S10-S18; doi:10.1038/modpathol.2010.133
引用
收藏
页码：S10 / S18
页数：9
相关论文
共 77 条
[1]   Increasing Prevalence of Papillary Thyroid Carcinoma in Recent Years in Greece: The Majority Are Incidental [J].
Alevizaki, Maria ;
Papageorgiou, George ;
Rentziou, Gianna ;
Saltiki, Katerina ;
Marafelia, Panagiota ;
Loukari, Eleni ;
Koutras, Dimitrios A. ;
Dimopoulos, Meletios-Athanassios .
THYROID, 2009, 19 (07) :749-754
[2]  
[Anonymous], 2003, AM J CLIN PATHOL
[3]   Encapsulated follicular variant of papillary thyroid carcinoma with bone metastases [J].
Baloch, ZW ;
LiVolsi, VA .
MODERN PATHOLOGY, 2000, 13 (08) :861-865
[4]  
CARCANGIU ML, 1985, CANCER-AM CANCER SOC, V55, P805, DOI 10.1002/1097-0142(19850215)55:4<805::AID-CNCR2820550419>3.0.CO
[5]  
2-Z
[6]   PAX8-PPARγ rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma [J].
Castro, P ;
Rebocho, AP ;
Soares, RJ ;
Magalhaes, J ;
Roque, L ;
Trovisco, V ;
de Castro, IV ;
Cardoso-de-Oliveira, M ;
Fonseca, E ;
Soares, P ;
Sobrinho-Simoes, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :213-220
[7]   H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid [J].
Castro, P. ;
Soares, P. ;
Gusmao, L. ;
Seruca, R. ;
Sobrinho-Simoes, M. .
ONCOGENE, 2006, 25 (33) :4620-4627
[8]   Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes [J].
Castro, P ;
Eknæs, M ;
Teixeira, MR ;
Danielsen, HE ;
Soares, P ;
Lothe, RA ;
Sobrinho-Simoes, M .
JOURNAL OF PATHOLOGY, 2005, 206 (03) :305-311
[9]   Fetal adenomas and minimally invasive follicular carcinomas of the thyroid frequently display a triploid or near triploid DNA pattern [J].
Castro, P ;
Sansonetty, F ;
Soares, P ;
Dias, A ;
Sobrinho-Simoes, M .
VIRCHOWS ARCHIV, 2001, 438 (04) :336-342
[10]   Follicular, papillary, and "hybrid" carcinomas of the thyroid [J].
Castro, P ;
Fonseca, E ;
Magalhaes, J ;
Sobrinho-Simoes, M .
ENDOCRINE PATHOLOGY, 2002, 13 (04) :313-320
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