Design and Synthesis of New 2-Aminobenzamide Derivatives Containing Benzothiazole and Phenylamine Moiety and Their Cytotoxicity

被引：1

作者：

Dinh Thi Cuc ^{[1
,2
]}

Nguyen Thi Hien ^{[3
]}

Vu Ngoc Doan ^{[4
]}

Tran Dang Thuan ^{[1
,2
]}

Dang Thi Tuyet Anh ^{[1
,2
]}

Nguyen Ha Thanh ^{[1
,2
]}

Trinh Thu Ha ^{[1
,2
]}

Nguyen Thi Nga ^{[5
]}

Nguyen Thi Kim Tuyet ^{[6
]}

Phan Van Kiem ^{[1
,7
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Grad Univ Sci & Technol, Hanoi, Vietnam

[2] VAST, Inst Chem, Hanoi, Vietnam

[3] Vietnam Natl Univ Agr, Fac Environm, Hanoi, Vietnam

[4] Le Quy Don Tech Univ, Hanoi, Vietnam

[5] Hanoi Med Coll, Hanoi, Vietnam

[6] Phutho Med Coll, Phu Tho, Vietnam

[7] VAST, Inst Marine Biochem, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2022年 / 17卷 / 07期

关键词：

benzothiazole; phenylamine; synthesis; 2-aminobenzamide; cytotoxic activity; HISTONE DEACETYLASE INHIBITOR; BIOLOGICAL EVALUATION; DISCOVERY;

D O I：

10.1177/1934578X221116188

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve new compounds including 2-aminobenzamide derivatives bearing benzothiazole and phenylamine moiety were designed and synthesized. The synthesized compounds were tested their cytotoxic activity against A549 and SW480 tumor cell lines. Compounds 3a and 3c exhibited cytotoxicity toward A549 cell line with IC50 values of 24.59 and 29.59 mu M, respectively.

引用

页数：6

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