PIVKA-II as a Potential New Biomarker for Hepatocellular Carcinoma - A Pilot Study

被引：29
作者：
Svobodova, Sarka [1 ,4 ,5 ]
Karlikova, Marie [1 ]
Topolcan, Ondrej [1 ]
Pecen, Ladislav [1 ]
Pestova, Martina [1 ]
Kott, Otto [6 ]
Treska, Vladislav [2 ,3 ]
Slouka, David [1 ]
Kucera, Radek [1 ]
机构：
[1] Charles Univ Prague, Dept Immunochem, Univ Hosp, Prague, Czech Republic
[2] Charles Univ Prague, Dept Surg, Univ Hosp, Prague, Czech Republic
[3] Charles Univ Prague, Fac Med Pilsen, Prague, Czech Republic
[4] Charles Univ Prague, Internal Med Dept 3, Prague, Czech Republic
[5] Charles Univ Prague, Med Fac 1, Prague, Czech Republic
[6] Univ West Bohemia, Fac Hlth Care Studies, Plzen, Czech Republic
来源：
IN VIVO | 2018年 / 32卷 / 06期
关键词：
PIVKA-II; AFP; hepatocellular carcinoma; biomarkers; predictive; GAMMA-CARBOXY PROTHROMBIN; VITAMIN-K ABSENCE; VIRAL-HEPATITIS; COMBINATION; DIAGNOSIS; PROTEIN;
D O I：
10.21873/invivo.11413
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: The aim of this study was to evaluate the clinical contribution of protein induced by vitamin K absence (PIVKA-II) for hepatocellular carcinoma (HCC) diagnostics and compare it with alpha-foetoprotein (AFP), a routinely used tumour marker. Materials and Methods: A total of 332 participants were enrolled in this study: 64 with HCC, 48 with liver metastases of colorectal cancer origin, 42 with liver cirrhosis and 178 healthy individuals. Serum levels of PIVKA-II were measured using the chemiluminescent assay of the Architect 1000i System (Abbott, USA) and AFP levels using the chemiluminescent assay by DxI 800 (Beckman Coulter, USA). Results: PIVKA-II achieved better clinical sensitivity than AFP and the difference in this sensitivity was statistically significant. PIVKA-II achieved the best sensitivity (96.9%) in distinguishing between the HCC and control groups with the proposed cut-off value of 60 mAU/ml. Conclusion: Our recommendation is for addition of PIVKA-II to the routine panel of HCC tumour markers.
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收藏
页码：1551 / 1554
页数：4
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