SYNTHESIS, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF (1Z,3Z)-4-ARYL-4-HYDROXY-1-(3,3-DIALKYL-3,4-DIHYDROISOQUINOLINE-1(2H)-YLIDENE)-BUT-3-EN-4-ONES

被引：7

作者：

Khalturina, V. V. ^{[1
]}

Shklyaev, Yu. V. ^{[1
]}

Makhmudov, R. R. ^{[2
]}

Maslivets, A. N. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Tech Chem, Ural Branch, Perm, Russia

[2] Perm State Univ, Inst Nat Sci, Perm, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

dioxinones; 1-methyl-3,4-dihydroisoquinolines; analgesic activity; anti-inflammatory activity;

D O I：

10.1007/s11094-010-0496-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It is established that 6-aryl-2,2-dimethyl-4H-1,3-dioxin-4-ones react with 3,3-dialkyl-1-methyl-3,4-dihydroisoquinolines with the formation of (1Z,3Z)-4-aryl-4-hydroxy-1-(3,3-dialkyl-3,4-dihydroisoquinoline-1(2H)-ylidene)-but-3-en-4-ones. The synthesized compounds were tested for anti-inflammatory and analgesic properties.

引用

页码：480 / 482

页数：3