Immunotherapy for Chronic Hepatitis B Virus Infection

被引：102

作者：

Bertoletti, Antonio ^{[1
,2
]}

Le Bert, Nina ^{[1
,2
]}

机构：

[1] Duke NUS Med Sch, Emerging Infect Dis Program, 8 Coll Rd, Singapore 169857, Singapore

[2] ASTAR, Viral Hepatitis Lab, Singapore Inst Clin Sci, Singapore, Singapore

来源：

GUT AND LIVER | 2018年 / 12卷 / 05期

关键词：

Vaccines; Hepatitis B; chronic; Therapeutics; Hepatitis B virus; CD8(+) T-CELLS; BONE-MARROW-TRANSPLANTATION; ANTIVIRAL IMMUNE-RESPONSE; CHRONIC HBV INFECTION; HEPATOCELLULAR-CARCINOMA; THERAPEUTIC VACCINATION; COMBINATION THERAPY; INTERFERON-ALPHA; SURFACE-ANTIGEN; INNATE IMMUNITY;

D O I：

10.5009/gnl17233

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

While new therapies for chronic hepatitis C virus infection have delivered remarkable cure rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal. Although current direct antiviral therapies are very efficient in controlling viral replication and limiting the progression to cirrhosis, these treatments require lifelong administration due to the frequent viral rebound upon treatment cessation, and immune modulation with interferon is only effective in a subgroup of patients. Specific immunotherapies can offer the possibility of eliminating or at least stably maintaining low levels of HBV replication under the control of a functional host antiviral response. Here, we review the development of immune cell therapy for HBV, highlighting the potential antiviral efficiency and potential toxicities in different groups of chronically infected HBV patients. We also discuss the chronic hepatitis B patient populations that best benefit from therapeutic immune interventions.

引用

页码：497 / 507

页数：11

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