Few constraints limit the design of quinone methide-oligonucleotide self-adducts for directing DNA alkylation

被引：31

作者：

Rossiter, Clifford S. ^{[1
]}

Modica, Emilia ^{[1
]}

Kumar, Dalip ^{[1
]}

Rokita, Steven E. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 05期

关键词：

STABILITY;

D O I：

10.1039/c0cc03317k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleotide sequences minimally containing adenosine, cytosine or guanosine are sufficient to form intrastrand oligonucleotide quinone methide self-adducts reversibly for subsequent alkylation of complementary DNA. The general lack of sequence restrictions should now allow for alkylation of most any target of interest although reaction is most efficient when the self-adducts contain guanine residues and do not form hairpin structures.

引用

页码：1476 / 1478

页数：3

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