Structure-Activity Relationship Studies of Antimicrobial Naphthoquinones Derived from Constituents of Tabebuia avellanedae

被引：9
|
作者：
Yamashita, Mitsuaki [1 ]
Sawano, Jun [1 ]
Umeda, Ryuji [1 ]
Tatsumi, Ayuka [1 ]
Kumeda, Yuko [2 ]
Iida, Akira [1 ]
机构：
[1] Kindai Univ, Sch Agr, Naka, Nara 6318505, Japan
[2] Osaka Prefecture Univ, Res Ctr Microorganism Control, Sakai, Osaka 5998531, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2021年 / 69卷 / 07期
关键词：
naphthoquinone; antimicrobial activity; Taheebo; methicillin-resistant Staphylococcus aureus (MRSA); ONE-POT SYNTHESIS; CONCISE SYNTHESIS; 1,4-NAPHTHOQUINONES; DERIVATIVES;
D O I：
10.1248/cpb.c21-00208
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, based on our previous study, derivatives of naphtho[2,3-b]furan-4,9-diones were synthesized and their antimicrobial activities were evaluated. The screening of these naphthoquinones revealed that the Iluorine containing NQ008 compound exhibited potent and broad antimicrobial activities against Grampositive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), Gram-negative bacteria, and fungi. The results of the ratio of the minimum bactericidal concentration (MBC) to the minimum inhibitory concentrations (MICs) and time-kill assays suggest that the mode of action of NQ008 is bactericidal. Additionall, the results of a drug resistance study revealed that NQ008 exhibited potent antibacterial activity and may delay the development of bacteria resistance. Furthermore, NQ008 exhibited preliminary antiviral activity against the swine influenza virus and Feline calicivirus.
引用
收藏
页码：661 / 673
页数：13
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