Recent Advances in the Development of Pyrazolopyridines as Anticancer Agents

被引：4

作者：

Gu, Xiaotong ^{[1
]}

Ma, Shutao ^{[1
]}

机构：

[1] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Cancer; anticancer agents; pyrazolopyridines; heterocyclic compounds; biological activity; structures-activity relationship; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; KINASE INHIBITORS; POTENT ANTITUMOR; DERIVATIVES; DESIGN; IDENTIFICATION; DISCOVERY; ACTIVATOR; CANCER;

D O I：

10.2174/1871520621666210901102832

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar in structure to purine, shows a variety of biological activities, which is mainly attributed to the antagonistic nature towards the natural purines in many biological processes. This has aroused enormous attention for many researchers. At present, a large number of new chemical entities containing pyrazolopyridine nucleus have been found as anticancer agents. In this review we summarize novel pyrazolopyridine-containing derivatives with biological activities. Furthermore, we outline the relationships between the structures of variously modified pyrazolopyridines and their anticancer activity.

引用

收藏

页码：1643 / 1657

页数：15

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