Actin dependent CD95 internalization is specific for Type I cells

被引：33

作者：

Algeciras-Schimnich, A ^{[1
]}

Peter, ME ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

FEBS LETTERS | 2003年 / 546卷 / 2-3期

关键词：

actin; apoptosis; caspase-8; endocytosis; Fas;

D O I：

10.1016/S0014-5793(03)00558-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD95 Type I and Type II cells differ in the requirement for mitochondrial contribution to the execution of apoptosis. Mitochondria are required to amplify the apoptosis signal only in Type II cells. Here we show that CD95 internalized in an actin dependent manner only in Type I cells and that the two CD95 apoptosis cell types differ in their threshold of active caspase-8 is linked to the cytoskeleton in different ways in the two cell types and that they have adapted to different levels of active caspase-8 generated at the activated receptor. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：185 / 188

页数：4

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