T regulatory cells, the evolution of targeted immunotherapy

被引：34
|
作者：
Nizar, S. [1 ,2 ]
Meyer, B. [1 ]
Galustian, C. [1 ]
Kumar, D. [2 ]
Dalgleish, A. [1 ]
机构：
[1] St Georges Univ London, Dept Cellular & Mol Med, London SW17 0RE, England
[2] St Georges Hosp NHS Trust, Dept Colorectal Surg, London, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1806卷 / 01期
关键词：
T regulatory; Tregs; FOXP3; Cancer; Immunotherapy; PHASE-II TRIAL; DENILEUKIN DIFTITOX; DENDRITIC CELLS; ANTITUMOR IMMUNITY; CTLA-4; BLOCKADE; TGF-BETA; PERIPHERAL-BLOOD; PROSTATE-CANCER; FUSION PROTEIN; IN-VITRO;
D O I：
10.1016/j.bbcan.2010.02.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T regulatory cells are able to suppress anti-tumour immunity in pre-clinical models and in patients. This review highlights the important discoveries in Treg immunology critical to the evolution of targeted immunotherapy. We also describe the therapeutic applications that are currently being assessed and their future potential. (C) 2010 Elsevier BM. All rights reserved.
引用
收藏
页码：7 / 17
页数：11
相关论文
共 50 条
  • [41] Regulatory cells and the effect of cancer immunotherapy
    Iglesias-Escudero, Maria
    Arias-Gonzalez, Noelia
    Martinez-Caceres, Eva
    MOLECULAR CANCER, 2023, 22 (01)
  • [42] Targeted immunotherapy of cancer with CAR T cells: achievements and challenges
    Grazyna Lipowska-Bhalla
    David E. Gilham
    Robert E. Hawkins
    Dominic G. Rothwell
    Cancer Immunology, Immunotherapy, 2012, 61 : 953 - 962
  • [43] Targeted immunotherapy of cancer with CAR T cells: achievements and challenges
    Lipowska-Bhalla, Grazyna
    Gilham, David E.
    Hawkins, Robert E.
    Rothwell, Dominic G.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (07) : 953 - 962
  • [44] Targeting regulatory T cells in tumors
    Liu, Chang
    Workman, Creg J.
    Vignali, Dario A. A.
    FEBS JOURNAL, 2016, 283 (14) : 2731 - 2748
  • [45] Regulatory T cells in children undergoing rush venom immunotherapy
    Ajduk, Jakov
    Turkalj, Mirjana
    Gagro, Alenka
    ALLERGY AND ASTHMA PROCEEDINGS, 2012, 33 (06) : 525 - 530
  • [46] CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
    Sobhani, Navid
    Tardiel-Cyril, Dana Rae
    Davtyan, Aram
    Generali, Daniele
    Roudi, Raheleh
    Li, Yong
    CANCERS, 2021, 13 (06) : 1 - 18
  • [47] Tumor Infiltrating Regulatory T Cells: Tractable Targets for Immunotherapy
    Khan, Adnan R.
    Dovedi, Simon J.
    Wilkinson, Robert W.
    Pritchard, David I.
    INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2010, 29 (05) : 461 - 484
  • [48] Therapeutic potential of FOXP3+ regulatory T cells and their interactions with dendritic cells
    Tran, Dat Q.
    Shevach, Ethan M.
    HUMAN IMMUNOLOGY, 2009, 70 (05) : 294 - 299
  • [49] Targeting γδ T cells for immunotherapy of HIV disease
    Pauza, C. David
    Riedel, David J.
    Gilliam, Bruce L.
    Redfield, Robert R.
    FUTURE VIROLOGY, 2011, 6 (01) : 73 - 84
  • [50] Immunotherapy with regulatory T and B cells in periodontitis
    Zou, Juan
    Zeng, Zijun
    Xie, Wen
    Zeng, Zhimei
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 109
12345