T regulatory cells, the evolution of targeted immunotherapy

被引：34
|
作者：
Nizar, S. [1 ,2 ]
Meyer, B. [1 ]
Galustian, C. [1 ]
Kumar, D. [2 ]
Dalgleish, A. [1 ]
机构：
[1] St Georges Univ London, Dept Cellular & Mol Med, London SW17 0RE, England
[2] St Georges Hosp NHS Trust, Dept Colorectal Surg, London, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1806卷 / 01期
关键词：
T regulatory; Tregs; FOXP3; Cancer; Immunotherapy; PHASE-II TRIAL; DENILEUKIN DIFTITOX; DENDRITIC CELLS; ANTITUMOR IMMUNITY; CTLA-4; BLOCKADE; TGF-BETA; PERIPHERAL-BLOOD; PROSTATE-CANCER; FUSION PROTEIN; IN-VITRO;
D O I：
10.1016/j.bbcan.2010.02.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T regulatory cells are able to suppress anti-tumour immunity in pre-clinical models and in patients. This review highlights the important discoveries in Treg immunology critical to the evolution of targeted immunotherapy. We also describe the therapeutic applications that are currently being assessed and their future potential. (C) 2010 Elsevier BM. All rights reserved.
引用
收藏
页码：7 / 17
页数：11
相关论文
共 50 条
  • [1] Immunotherapy of Cancer by Targeting Regulatory T cells
    Chen, Bo-Jin
    Zhao, Jing-Wen
    Zhang, Da-Hong
    Zheng, Ai-Hong
    Wu, Guo-Qing
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 104
  • [2] Regulatory T cells in cancer immunotherapy
    Tanaka, Atsushi
    Sakaguchi, Shimon
    CELL RESEARCH, 2017, 27 (01) : 109 - 118
  • [3] A new target of radiotherapy combined with immunotherapy: regulatory T cells
    Song, Dongmei
    Ding, Yun
    FRONTIERS IN IMMUNOLOGY, 2024, 14
  • [4] Targeting regulatory T cells for immunotherapy in melanoma
    Huang, Lili
    Guo, Yeye
    Liu, Shujing
    Wang, Huaishan
    Zhu, Jinjin
    Ou, Lingling
    Xu, Xiaowei
    MOLECULAR BIOMEDICINE, 2021, 2 (01):
  • [5] Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy
    Xie, Feng
    Liang, Rui
    Li, Dan
    Li, Bin
    ENGINEERING, 2019, 5 (01) : 132 - 139
  • [6] Immunotherapy Approaches Targeting Regulatory T-Cells
    Onishi, Hideya
    Morisaki, Takashi
    Katano, Mitsuo
    ANTICANCER RESEARCH, 2012, 32 (03) : 997 - 1003
  • [7] Regulatory T cells in cancer immunotherapy
    Atsushi Tanaka
    Shimon Sakaguchi
    Cell Research, 2017, 27 : 109 - 118
  • [8] Immunotherapy with regulatory T cells in transplantation
    Peters, J. H.
    Koenen, H. J. P. M.
    Hilbrands, L. B.
    Joosten, I.
    IMMUNOTHERAPY, 2009, 1 (05) : 855 - 871
  • [9] T-regulatory cell modulation: the future of cancer immunotherapy?
    Nizar, S.
    Copier, J.
    Meyer, B.
    Bodman-Smith, M.
    Galustian, C.
    Kumar, D.
    Dalgleish, A.
    BRITISH JOURNAL OF CANCER, 2009, 100 (11) : 1697 - 1703
  • [10] Regulatory T cells in gastrointestinal tumors
    Raghavan, Sukanya
    Quiding-Jarbrink, Marianne
    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2011, 5 (04) : 489 - 501
12345