The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases

被引：21
作者：
Yang, Qing [1 ,2 ]
Wang, Wenqian [2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Breast Surg, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 2, Dept Plast Surg, Wenzhou, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
基金：
中国国家自然科学基金;
关键词：
heme oxygenase-1; nuclear translocation; noncanonical function; tumorigenesis; inflammation; anticancer therapy; BROWN ADIPOSE-TISSUE; NF-E2-RELATED FACTOR-2 NRF2; ENDOTHELIAL GROWTH-FACTOR; PROSTATE-CANCER CELLS; SIGNALING PATHWAY; OXIDATIVE STRESS; UP-REGULATION; ANDROGEN RECEPTOR; TUMOR-GROWTH; TRANSGLUTAMINASE ACTIVITY;
D O I：
10.3389/fcell.2022.890186
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), free iron and biliverdin, which could then be converted to bilirubin by biliverdin reductase. HO-1 exhibits cytoprotective effects of anti-apoptosis, anti-oxidation, and anti-inflammation via these byproducts generated during the above process. In the last few years, despite the canonical function of HO-1 and possible biological significance of its byproducts, a noncanonical function, through which HO-1 exhibits functions in diseases independent of its enzyme activity, also has been reported. In this review, the noncanonical functions of HO-1 and its translocation in other subcellular compartments are summarized. More importantly, we emphasize the critical role of HO-1 nuclear translocation in human diseases. Intriguingly, this translocation was linked to tumorigenesis and tumor progression in lung, prostate, head, and neck squamous cell carcinomas and chronic myeloid leukemia. Given the importance of HO-1 nuclear translocation in human diseases, nuclear HO-1 as a novel target might be attractive for the prevention and treatment of human diseases.
引用
收藏
页数：12
相关论文
共 139 条
[41]   Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells [J].
Gueron, Geraldine ;
De Siervi, Adriana ;
Ferrando, Mercedes ;
Salierno, Marcelo ;
De Luca, Paola ;
Elguero, Belen ;
Meiss, Roberto ;
Navone, Nora ;
Vazquez, Elba S. .
MOLECULAR CANCER RESEARCH, 2009, 7 (11) :1745-1755
[42]   Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease [J].
Gupta, Gaurav ;
Dahiya, Rajiv ;
Singh, Yogendra ;
Mishra, Anurag ;
Verma, Aseem ;
Gothwal, Sunil Kumar ;
Aljabali, Alaa A. A. ;
Dureja, Harish ;
Prasher, Parteek ;
Negi, Poonam ;
Kapoor, Deepak N. ;
Goyal, Rohit ;
Tambuwala, Murtaza M. ;
Chellappan, Dinesh K. ;
Dua, Kamal .
CHEMICO-BIOLOGICAL INTERACTIONS, 2020, 317
[43]   ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation [J].
Habelhah, H ;
Shah, K ;
Huang, L ;
Ostareck-Lederer, A ;
Burlingame, AL ;
Shokat, KM ;
Hentze, MW ;
Ronai, Z .
NATURE CELL BIOLOGY, 2001, 3 (03) :325-330
[44]   Interactions between HIV Rev and nuclear import and export factors:: The Rev nuclear localisation signal mediates specific binding to human importin-β [J].
Henderson, BR ;
Percipalle, P .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (05) :693-707
[45]   Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness [J].
Hsu, F-F ;
Chiang, M-T ;
Li, F-A ;
Yeh, C-T ;
Lee, W-H ;
Chau, L-Y .
ONCOGENE, 2017, 36 (49) :6805-6814
[46]  
Hsu FF, 2015, ONCOGENE, V34, P2360, DOI 10.1038/onc.2014.166
[47]   Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury [J].
Huang, Jing ;
Shen, Xiu-Da ;
Yue, Shi ;
Zhu, Jianjun ;
Gao, Feng ;
Zhai, Yuan ;
Busuttil, Ronald W. ;
Ke, Bibo ;
Kupiec-Weglinski, Jerzy W. .
MOLECULAR MEDICINE, 2014, 20 :448-455
[48]  
Huang S, 2000, CANCER RES, V60, P5334
[49]   Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis [J].
Huang, SY ;
Pettaway, CA ;
Uehara, H ;
Bucana, CD ;
Fidler, IJ .
ONCOGENE, 2001, 20 (31) :4188-4197
[50]   Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map [J].
Huynh, Jennifer ;
Chand, Ashwini ;
Gough, Daniel ;
Ernst, Matthias .
NATURE REVIEWS CANCER, 2019, 19 (02) :82-96
12345678910