Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

被引：18

作者：

Guo, Yahui ^{[1
,2
,3
]}

Zhang, Yao ^{[1
,4
]}

Pei, Renjun ^{[3
]}

Cheng, Yuliang ^{[1
,4
]}

Xie, Yunfei ^{[1
,4
]}

Yu, Hang ^{[1
,4
]}

Yao, Weirong ^{[1
,4
]}

Li, Hung-Wing ^{[2
]}

Qian, He ^{[1
,4
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Sch Food Sci & Technol, Wuxi 214122, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[3] Chinese Acad Sci, CAS Key Lab Nanobio Interface, Suzhou Inst Nanotech & Nanobion, Ruoshui Rd, Suzhou 215123, Peoples R China

[4] Jiangnan Univ, Joint Int Res Lab Food Safety, Wuxi 214122, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2019年 / 281卷

基金：

国家重点研发计划; 美国国家科学基金会;

关键词：

G-insertion enhanced fluorescence; Silver nanoclusters; Food adulteration assay; Visual probe; TEMPLATED SILVER NANOCLUSTERS; CAPTOPRIL; PHARMACEUTICALS; QUANTITATION; REAGENT; DESIGN; PROBES;

D O I：

10.1016/j.snb.2018.10.101

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C(6)G(5)G(6)) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.

引用

页码：493 / 498

页数：6

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